U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    REG3G regenerating family member 3 gamma [ Homo sapiens (human) ]

    Gene ID: 130120, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    REG3Gprovided by HGNC
    Official Full Name
    regenerating family member 3 gammaprovided by HGNC
    Primary source
    HGNC:HGNC:29595
    See related
    Ensembl:ENSG00000143954 MIM:609933; AllianceGenome:HGNC:29595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAP1B; PAPIB; PAP IB; PAP-1B; UNQ429; LPPM429; REG III; REG-III
    Summary
    This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]
    Expression
    Restricted expression toward testis (RPKM 33.7) See more
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See REG3G in Genome Data Viewer
    Location:
    2p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (79025702..79028501)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (79025993..79028792)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (79252828..79255627)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 812, pseudogene Neighboring gene uncharacterized LOC105374822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:79220523-79221189 Neighboring gene regenerating family member 1 beta Neighboring gene regenerating family member 1 alpha

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Role of oncogenic REGγ in cancer. Shen M, et al. Biomed Pharmacother, 2020 Oct. PMID 32935661
    2. PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication. Laurine E, et al. Biochim Biophys Acta, 2005 Mar 10. PMID 15777617
    3. Proteasome-dependent degradation of Smad7 is critical for lung cancer metastasis. Tong L, et al. Cell Death Differ, 2020 Jun. PMID 31767934, Free PMC Article
    4. Helicobacter pylori CagA triggers expression of the bactericidal lectin REG3γ via gastric STAT3 activation. Lee KS, et al. PLoS One, 2012. PMID 22312430, Free PMC Article
    5. Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III. Nata K, et al. Gene, 2004 Sep 29. PMID 15556304

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteasome-dependent degradation of Smad7 is critical for lung cancer metastasis.
      Title: Proteasome-dependent degradation of Smad7 is critical for lung cancer metastasis.
    2. Myocardial Accumulations of Reg3A, Reg3gamma and Oncostatin M Are Associated with the Formation of Granulomata in Patients with Cardiac Sarcoidosis.
      Title: Myocardial Accumulations of Reg3A, Reg3γ and Oncostatin M Are Associated with the Formation of Granulomata in Patients with Cardiac Sarcoidosis.
    3. Role of oncogenic REGgamma in cancer.
      Title: Role of oncogenic REGγ in cancer.
    4. This gene encodes a secreted peptide that displays antimicrobial activity against Gram-positive bacteria.
      Title: Symbiotic bacteria direct expression of an intestinal bactericidal lectin.
    5. a model of CagA-directed REG3gamma expression in gastric epithelial cells via activation of the IL-11/gp130/STAT3 pathway
      Title: Helicobacter pylori CagA triggers expression of the bactericidal lectin REG3γ via gastric STAT3 activation.
    6. REG III was identified and expressed predominantly in pancreas and testis, but not in small intestine
      Title: Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III.
    7. PAP IB represents a good example of duplication and divergence, probably with the acquisition of new functions, thus participating in the evolution of the protein repertoire.
      Title: PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC118998, MGC118999, MGC119001

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oligosaccharide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in MyD88-dependent toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of keratinocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of keratinocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    regenerating islet-derived protein 3-gamma
    Names
    REG-3-gamma
    pancreatitis-associated protein 1B
    pancreatitis-associated protein IB
    reg III-gamma
    regenerating gene III
    regenerating islet-derived 3 gamma
    regenerating islet-derived protein III-gamma

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008387.3 → NP_001008388.1  regenerating islet-derived protein 3-gamma isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AB161038, AK292595
      Consensus CDS
      CCDS1962.1
      UniProtKB/Swiss-Prot
      A8K980, D6W5J6, Q3SYE4, Q3SYE6, Q6FH18, Q6UW15
      Related
      ENSP00000272324.5, ENST00000272324.10
      Conserved Domains (1) summary
      cd03594
      Location:40 → 173
      CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

    2. NM_001270040.2 → NP_001256969.1  regenerating islet-derived protein 3-gamma isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AK292595, BC103852, BX280299
      Consensus CDS
      CCDS58714.1
      UniProtKB/Swiss-Prot
      Q6UW15
      Related
      ENSP00000387105.1, ENST00000409471.1
      Conserved Domains (1) summary
      cl02432
      Location:40 → 127
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    3. NM_198448.4 → NP_940850.1  regenerating islet-derived protein 3-gamma isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK292595
      Consensus CDS
      CCDS1962.1
      UniProtKB/Swiss-Prot
      A8K980, D6W5J6, Q3SYE4, Q3SYE6, Q6FH18, Q6UW15
      Related
      ENSP00000377475.2, ENST00000393897.6
      Conserved Domains (1) summary
      cd03594
      Location:40 → 173
      CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      79025702..79028501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264135.3 → XP_005264192.1  regenerating islet-derived protein 3-gamma isoform X1

      UniProtKB/Swiss-Prot
      A8K980, D6W5J6, Q3SYE4, Q3SYE6, Q6FH18, Q6UW15
      Conserved Domains (1) summary
      cd03594
      Location:40 → 173
      CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

    2. XM_024452693.2 → XP_024308461.1  regenerating islet-derived protein 3-gamma isoform X2

      Conserved Domains (1) summary
      cl02432
      Location:40 → 127
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    3. XM_024452694.2 → XP_024308462.1  regenerating islet-derived protein 3-gamma isoform X2

      Conserved Domains (1) summary
      cl02432
      Location:40 → 127
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      79025993..79028792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340515.1 → XP_054196490.1  regenerating islet-derived protein 3-gamma isoform X2

    2. XM_054340514.1 → XP_054196489.1  regenerating islet-derived protein 3-gamma isoform X2

    3. XM_054340513.1 → XP_054196488.1  regenerating islet-derived protein 3-gamma isoform X1

      UniProtKB/Swiss-Prot
      A8K980, D6W5J6, Q3SYE4, Q3SYE6, Q6FH18, Q6UW15
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UW15.1 GenPept UniProtKB/Swiss-Prot:Q6UW15

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous