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    Plppr5 phospholipid phosphatase related 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310812, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Plppr5provided by RGD
    Official Full Name
    phospholipid phosphatase related 5provided by RGD
    Primary source
    RGD:1309567
    See related
    EnsemblRapid:ENSRNOG00000016878 AllianceGenome:RGD:1309567
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lppr5; PRG-5; Pap2d; RGD1309567
    Summary
    Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in several processes, including phospholipid dephosphorylation; phospholipid metabolic process; and positive regulation of cell projection organization. Predicted to be active in plasma membrane. Orthologous to human PLPPR5 (phospholipid phosphatase related 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 74.6), Testes (RPKM 17.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plppr5 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (208143058..208422836)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (205525466..205737892)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219895141..220102333, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548639 Neighboring gene palmdelphin Neighboring gene phospholipid phosphatase related 4 Neighboring gene uncharacterized LOC134485953 Neighboring gene sorting nexin 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Plasticity-related gene 5 (PRG5) induces filopodia and neurite growth and impedes lysophosphatidic acid- and nogo-A-mediated axonal retraction. Broggini T, et al. Mol Biol Cell, 2010 Feb 15. PMID 20032306, Free PMC Article
    2. Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. Savaskan NE, et al. Eur J Neurosci, 2004 Jan. PMID 14750979
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid phosphatase-related protein type 5
    Names
    lipid phosphate phosphatase-related protein type 5
    phosphatidic acid phosphatase type 2
    phosphatidic acid phosphatase type 2d
    plasticity-related protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107720.1 → NP_001101190.1  phospholipid phosphatase-related protein type 5

      See identical proteins and their annotated locations for NP_001101190.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473952
      UniProtKB/TrEMBL
      A0A8I6B5V9, A6HVB8, B3VQM3, F7EXV2
      Related
      ENSRNOP00000022905.5, ENSRNOT00000022905.7
      Conserved Domains (1) summary
      cd03384
      Location:118 → 267
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      208143058..208422836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281942.1 → XP_063138012.1  phospholipid phosphatase-related protein type 5 isoform X1

    2. XM_008761462.4 → XP_008759684.2  phospholipid phosphatase-related protein type 5 isoform X3

      UniProtKB/TrEMBL
      A0A8I6B5V9
      Conserved Domains (1) summary
      cd03384
      Location:125 → 274
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    3. XM_039102433.2 → XP_038958361.1  phospholipid phosphatase-related protein type 5 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZQK9, A0A8I6B5V9
      Related
      ENSRNOP00000080680.1, ENSRNOT00000111424.3
      Conserved Domains (1) summary
      cd03384
      Location:125 → 274
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    4. XM_063281943.1 → XP_063138013.1  phospholipid phosphatase-related protein type 5 isoform X5

    5. XM_039102432.2 → XP_038958360.1  phospholipid phosphatase-related protein type 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I6B5V9
      Related
      ENSRNOP00000083757.2, ENSRNOT00000113318.2
      Conserved Domains (1) summary
      cd03384
      Location:118 → 267
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
    Nucleotide Protein Strain
    Heading Accession and Version

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