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    TACSTD2 tumor associated calcium signal transducer 2 [ Homo sapiens (human) ]

    Gene ID: 4070, updated on 2-May-2024

    Summary

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    Official Symbol
    TACSTD2provided by HGNC
    Official Full Name
    tumor associated calcium signal transducer 2provided by HGNC
    Primary source
    HGNC:HGNC:11530
    See related
    Ensembl:ENSG00000184292 MIM:137290; AllianceGenome:HGNC:11530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
    Summary
    This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
    Orthologs
    mouse all
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    Genomic context

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    See TACSTD2 in Genome Data Viewer
    Location:
    1p32.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (58575433..58577252, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (58453397..58455216, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (59041105..59042924, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DAB adaptor protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:59011807-59012433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1085 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:59041692-59042387 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:59042388-59043082 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:59049763-59050962 Neighboring gene Sharpr-MPRA regulatory region 6655 Neighboring gene Sharpr-MPRA regulatory region 14294 Neighboring gene RNA, 7SL, cytoplasmic 713, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1086 Neighboring gene OMA1 zinc metallopeptidase Neighboring gene adenylate kinase 2 pseudogene 1 Neighboring gene Myb like, SWIRM and MPN domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeting Trop-2 in cancer: Recent research progress and clinical application. Qiu S, et al. Biochim Biophys Acta Rev Cancer, 2023 Jul. PMID 37121444
    2. Trophoblast cell-surface antigen 2 (TROP2) expression in triple-negative breast cancer. Jeon Y, et al. BMC Cancer, 2022 Sep 24. PMID 36153494, Free PMC Article
    3. Alteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance. Zhu J, et al. Breast Cancer, 2022 Nov. PMID 35882754, Free PMC Article
    4. Trophoblast Cell Surface Antigen 2 gene (TACSTD2) expression in primary breast cancer. Vidula N, et al. Breast Cancer Res Treat, 2022 Aug. PMID 35789445
    5. Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma. Erber R, et al. Int J Mol Sci, 2021 Dec 22. PMID 35008509, Free PMC Article

    See all (156) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma.
      Title: Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma.
    2. Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.
      Title: Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.
    3. TROP2 Is Associated with Primary Resistance to Immune Checkpoint Inhibition in Patients with Advanced Non-Small Cell Lung Cancer.
      Title: TROP2 Is Associated with Primary Resistance to Immune Checkpoint Inhibition in Patients with Advanced Non-Small Cell Lung Cancer.
    4. DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells.
      Title: DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells.
    5. Trop-2 Is Highly Expressed in Early Luminal-Like Breast Cancer.
      Title: Trop-2 Is Highly Expressed in Early Luminal-Like Breast Cancer.
    6. High levels of expression of Trop-2 in thymic epithelial tumors.
      Title: High levels of expression of Trop-2 in thymic epithelial tumors.
    7. TROP2 translation mediated by dual m[6]A/m[7]G RNA modifications promotes bladder cancer development.
      Title: TROP2 translation mediated by dual m(6)A/m(7)G RNA modifications promotes bladder cancer development.
    8. Trophoblast cell surface antigen-2 phosphorylation triggered by binding of galectin-3 drives metastasis through down-regulation of E-cadherin.
      Title: Trophoblast cell surface antigen-2 phosphorylation triggered by binding of galectin-3 drives metastasis through down-regulation of E-cadherin.
    9. TROP-2 is widely expressed in vulvar squamous cell carcinoma and represents a potential new therapeutic target.
      Title: TROP-2 is widely expressed in vulvar squamous cell carcinoma and represents a potential new therapeutic target.
    10. Targeting Trop-2 in cancer: Recent research progress and clinical application.
      Title: Targeting Trop-2 in cancer: Recent research progress and clinical application.
    Submit: New GeneRIF Correction See all GeneRIFs (131)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Lattice corneal dystrophy Type III
    MedGen: C0339273 OMIM: 204870 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of branching involved in ureteric bud morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of epithelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of ruffle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of substrate adhesion-dependent cell spreading ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of stem cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basal plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tumor-associated calcium signal transducer 2
    Names
    40kD glycoprotein, identified by monoclonal antibody GA733
    cell surface glycoprotein TROP2
    cell surface glycoprotein Trop-2
    epithelial glycoprotein-1
    gastrointestinal tumor-associated antigen GA7331
    membrane component, chromosome 1, surface marker 1
    pancreatic carcinoma marker protein GA733-1
    pancreatic carcinoma marker protein GA7331
    trophoblast cell surface antigen 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016237.1 RefSeqGene

      Range
      5243..7062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002353.3 → NP_002344.2  tumor-associated calcium signal transducer 2 precursor

      See identical proteins and their annotated locations for NP_002344.2

      Status: REVIEWED

      Source sequence(s)
      AI201870, AW052118, BM765888, CD722224, CV027795
      Consensus CDS
      CCDS609.1
      UniProtKB/Swiss-Prot
      P09758, Q15658, Q6FG48, Q7Z7Q4, Q96QD2
      UniProtKB/TrEMBL
      C5IX07
      Related
      ENSP00000360269.2, ENST00000371225.4
      Conserved Domains (1) summary
      cd00191
      Location:72 → 145
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      58575433..58577252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      58453397..58455216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09758.3 GenPept UniProtKB/Swiss-Prot:P09758

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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