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    Ces1d carboxylesterase 1D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113902, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ces1dprovided by RGD
    Official Full Name
    carboxylesterase 1Dprovided by RGD
    Primary source
    RGD:70896
    See related
    EnsemblRapid:ENSRNOG00000015438 AllianceGenome:RGD:70896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ces3
    Summary
    Enables retinyl-palmitate esterase activity. Predicted to be involved in several processes, including cellular response to cholesterol; cholesterol homeostasis; and regulation of steroid metabolic process. Predicted to act upstream of or within several processes, including cellular lipid catabolic process; circadian temperature homeostasis; and cold-induced thermogenesis. Located in intracellular membrane-bounded organelle. Biomarker of liver cancer. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 1509.9), Lung (RPKM 1198.8) and 6 other tissues See more
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    Genomic context

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    See Ces1d in Genome Data Viewer
    Location:
    19p11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (30046494..30085039)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (13873490..13912035)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (15195514..15239827)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carboxylesterase 1F Neighboring gene carboxylesterase 1E Neighboring gene carboxylesterase 1C Neighboring gene uncharacterized LOC134483613 Neighboring gene carboxylesterase 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Carboxylesterase 1 polymorphisms are associated with clinical outcomes in gastroenteric cancer patients treated with capecitabine. Liu D, et al. Cancer Chemother Pharmacol, 2021 May. PMID 33586000
    2. Hepatic carboxylesterase 3 (Ces3/Tgh) is downregulated in the early stages of liver cancer development in the rat. Quiroga AD, et al. Biochim Biophys Acta, 2016 Nov. PMID 27523631
    3. Mutation of residues 423 (Met/Ile), 444 (Thr/Met), and 506 (Asn/Ser) confer cholesteryl esterase activity on rat lung carboxylesterase. Ser-506 is required for activation by cAMP-dependent protein kinase. Wallace TJ, et al. J Biol Chem, 2001 Aug 31. PMID 11429416
    4. The carboxylesterase family exhibits C-terminal sequence diversity reflecting the presence or absence of endoplasmic-reticulum-retention sequences. Medda S, et al. Eur J Biochem, 1992 Jun 15. PMID 1606962
    5. Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma. Capece D, et al. J Clin Invest, 2021 Jun 1. PMID 33878036, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty-acyl-ethyl-ester synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinyl-palmitate esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol ester esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sterol ester esterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables triacylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in acylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in acylglycerol catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to cold ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within circadian temperature homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cytosolic lipolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in medium-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of bile acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reverse cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within short-chain fatty acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within very-low-density lipoprotein particle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    carboxylesterase 1D
    Names
    ES-HVEL
    FAEE synthase
    carboxyesterase ES-10
    carboxylesterase 3
    fatty acid ethyl ester synthase
    liver carboxylesterase 10
    pI 6.1 esterase
    NP_579829.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133295.3 → NP_579829.3  carboxylesterase 1D precursor

      See identical proteins and their annotated locations for NP_579829.3

      Status: VALIDATED

      Source sequence(s)
      BC061789, CF111142, CO574231
      UniProtKB/Swiss-Prot
      P16303, Q64574, Q6P785, Q91YG2, Q9QUX7, Q9R135
      UniProtKB/TrEMBL
      A0A0G2JY66, A6KD48
      Related
      ENSRNOP00000070536.2, ENSRNOT00000090865.3
      Conserved Domains (2) summary
      COG0657
      Location:121 → 239
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:24 → 545
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      30046494..30085039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16303.2 GenPept UniProtKB/Swiss-Prot:P16303

    Gene LinkOut

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