Pdgfrl platelet-derived growth factor receptor-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pdgfrlprovided by RGD
Official Full Name: platelet-derived growth factor receptor-likeprovided by RGD
Primary source: RGD:1308028
See related: EnsemblRapid:ENSRNOG00000010832 AllianceGenome:RGD:1308028
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in colorectal cancer and hepatocellular carcinoma. Orthologous to human PDGFRL (platelet derived growth factor receptor like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 90.6), Heart (RPKM 47.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (58051421..58111327, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (51347929..51407850, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (54386269..54450426, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrate that in RBA-1 cells, activation of c-Jun/AP-1 by a CaMKII-dependent PI3K/Akt-JNK activation mediated through transactivation of PDGFR is essential for up-regulation of MMP-9 and cell migration induced by lipoteichoic acid.
Title: Calmodulin kinase II-dependent transactivation of PDGF receptors mediates astrocytic MMP-9 expression and cell motility induced by lipoteichoic acid.

Submit: New GeneRIF Correction

General gene information

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Markers

AV013190 (e-PCR)
- UniSTS:165577

RH133543 (e-PCR)
- UniSTS:216826

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: platelet-derived growth factor receptor-like protein

Names: PDGFR-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011921.1 → NP_001011921.1 platelet-derived growth factor receptor-like protein precursor

See identical proteins and their annotated locations for NP_001011921.1

Status: PROVISIONAL

Source sequence(s)

BC086555

UniProtKB/Swiss-Prot

Q5RJP7

UniProtKB/TrEMBL

A0A8I6A5A7

Related

ENSRNOP00000014623.5, ENSRNOT00000014623.7

Conserved Domains (3) summary

smart00410
Location:83 → 143

IG_like; Immunoglobulin like

pfam07679
Location:272 → 373

I-set; Immunoglobulin I-set domain

cl11960
Location:293 → 372

Ig; Immunoglobulin domain