1810009J06Rik RIKEN cDNA 1810009J06 gene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: 1810009J06Rikprovided by MGI
Official Full Name: RIKEN cDNA 1810009J06 geneprovided by MGI
Primary source: MGI:MGI:1920876
See related: Ensembl:ENSMUSG00000094808 AllianceGenome:MGI:1920876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 6 B1; 6 19.02 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (40941706..40945361)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (40964772..40968427)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3
Title: Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493124

NoName (e-PCR)
- UniSTS:493977

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein LOC73626

Names: trypsinogen 5

NP_076196.1

EC 3.4.21.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_006980.1

Range

73978..77633

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_023707.3 → NP_076196.1 uncharacterized protein LOC73626 precursor

See identical proteins and their annotated locations for NP_076196.1

Status: VALIDATED

Source sequence(s)

AC161768

Consensus CDS

CCDS20042.1

UniProtKB/TrEMBL

Q7TT42, Q9CPN7

Related

ENSMUSP00000075935.6, ENSMUST00000076638.7

Conserved Domains (2) summary

smart00020
Location:23 → 240

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:24 → 243

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...