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    ZNF326 zinc finger protein 326 [ Homo sapiens (human) ]

    Gene ID: 284695, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF326provided by HGNC
    Official Full Name
    zinc finger protein 326provided by HGNC
    Primary source
    HGNC:HGNC:14104
    See related
    Ensembl:ENSG00000162664 MIM:614601; AllianceGenome:HGNC:14104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZIRD; ZAN75; Zfp326; dJ871E2.1
    Summary
    Enables RNA polymerase II complex binding activity. Involved in regulation of DNA-templated transcription elongation and regulation of RNA splicing. Located in nucleoplasm. Part of DBIRD complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 6.2), endometrium (RPKM 3.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF326 in Genome Data Viewer
    Location:
    1p22.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (89995110..90035533)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (89838332..89878758)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (90460669..90501092)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:90460321-90460887 and GRCh37_chr1:90460888-90461453 Neighboring gene RN7SK pseudogene 272 Neighboring gene gem nuclear organelle associated protein 8 pseudogene 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:90528154-90528660 Neighboring gene uncharacterized LOC105378848 Neighboring gene NANOG hESC enhancer GRCh37_chr1:90597824-90598325 Neighboring gene NANOG hESC enhancer GRCh37_chr1:90642009-90642541 Neighboring gene uncharacterized LOC105378849 Neighboring gene RNA, U6 small nuclear 695, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A long non-coding RNA OLBC15 promotes triple-negative breast cancer progression via enhancing ZNF326 degradation. Deng C, et al. J Clin Lab Anal, 2020 Aug. PMID 32329931, Free PMC Article
    2. Convergent evidence from mouse and human studies suggests the involvement of zinc finger protein 326 gene in antidepressant treatment response. Liou YJ, et al. PLoS One, 2012. PMID 22666313, Free PMC Article
    3. ZNF326 promotes a malignant phenotype of breast cancer by interacting with DBC1. Yu X, et al. Mol Carcinog, 2018 Dec. PMID 30175866
    4. ZNF326 promotes proliferation of non-small cell lung cancer cells by regulating ERCC1 expression. Wu J, et al. Lab Invest, 2019 Feb. PMID 30401956
    5. MicroRNA-136-5p regulates gemcitabine resistance in pancreatic cancer via down-regulating ZNF32. Xu Y, et al. Eur Rev Med Pharmacol Sci, 2020 Oct. PMID 33155203

    See all (131) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-136-5p regulates gemcitabine resistance in pancreatic cancer via down-regulating ZNF32.
      Title: MicroRNA-136-5p regulates gemcitabine resistance in pancreatic cancer via down-regulating ZNF32.
    2. A long non-coding RNA OLBC15 promotes triple-negative breast cancer progression via enhancing ZNF326 degradation.
      Title: A long non-coding RNA OLBC15 promotes triple-negative breast cancer progression via enhancing ZNF326 degradation.
    3. Transcription Factor ZNF326 Upregulates the Expression of ERCC1 and HDAC7 and its Clinicopathologic Significance in Glioma.
      Title: Transcription Factor ZNF326 Upregulates the Expression of ERCC1 and HDAC7 and its Clinicopathologic Significance in Glioma.
    4. Studied role of zinc finger protein 326 (ZNF326) in promotion of excision repair cross-complementation group 1 (ERCC1) expression in non-small cell lung cancer (NSCLC) cells.
      Title: ZNF326 promotes proliferation of non-small cell lung cancer cells by regulating ERCC1 expression.
    5. Data provide evidence that the high nuclear expression of ZNF326 in breast cancer was closely related to advanced pTNM staging, positive lymph node metastasis, and poor prognosis in patients with breast cancer. ZNF326 promotes proliferation, invasiveness, and xenograft formation by upregulating MMP7, EMT, and cell cycle-related factors by interacting with DBC1.
      Title: ZNF326 promotes a malignant phenotype of breast cancer by interacting with DBC1.
    6. High ZNF326 expression is associated with glioma.
      Title: ZNF326 promotes malignant phenotype of glioma by up-regulating HDAC7 expression and activating Wnt pathway.
    7. Data indicate that ZNF326 is an interaction partner and substrate of the PRMT5/WDR77 complex.
      Title: The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.
    8. involvement of the Zfp326 and ZNF326 genes in antidepressant treatment response
      Title: Convergent evidence from mouse and human studies suggests the involvement of zinc finger protein 326 gene in antidepressant treatment response.
    9. data indicate that the DBIRD complex (consisting of DBC1 and ZNF326) acts at the interface between mRNP particles and RNAPII, integrating transcript elongation with the regulation of alternative splicing
      Title: DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Zinc finger protein 326 (ZNF326) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20403, MGC61591

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables RNA polymerase II complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DBIRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DBIRD complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DBIRD complex subunit ZNF326
    Names
    ZNF-protein interacting with nuclear mRNPs and DBC1
    zinc finger protein interacting with mRNPs and DBC1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320185.2 → NP_001307114.1  DBIRD complex subunit ZNF326 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 4, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK303707, AL161797, BC014899, BU676987, CN299618
      Consensus CDS
      CCDS81351.1
      UniProtKB/TrEMBL
      A0A0A0MRN4
      Related
      ENSP00000359476.2, ENST00000370447.3
      Conserved Domains (1) summary
      pfam04988
      Location:223 → 388
      AKAP95; A-kinase anchoring protein 95 (AKAP95)

    2. NM_181781.4 → NP_861446.2  DBIRD complex subunit ZNF326 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK303707, AL161797, BC014899, BC038454, BU676987, CN299618
      UniProtKB/Swiss-Prot
      Q5BKZ1
      Conserved Domains (1) summary
      pfam04988
      Location:106 → 271
      AKAP95; A-kinase anchoring protein 95 (AKAP95)

    3. NM_182975.4 → NP_892020.1  DBIRD complex subunit ZNF326 isoform 3

      See identical proteins and their annotated locations for NP_892020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' exon structure and differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (3) has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AK000410, BC053888, CN299618
      Consensus CDS
      CCDS728.1
      UniProtKB/Swiss-Prot
      Q5BKZ1
      Related
      ENSP00000355318.5, ENST00000361911.9

    4. NM_182976.4 → NP_892021.1  DBIRD complex subunit ZNF326 isoform 1

      See identical proteins and their annotated locations for NP_892021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK303707, AL161797, BC090866, BU676987, CN299618
      Consensus CDS
      CCDS727.1
      UniProtKB/Swiss-Prot
      A8MYX1, B4DLN0, B4E179, Q5BKZ1, Q5VW93, Q5VW94, Q5VW96, Q5VW97, Q6NSA2, Q7Z638, Q7Z6C2
      Related
      ENSP00000340796.4, ENST00000340281.9
      Conserved Domains (1) summary
      pfam04988
      Location:312 → 477
      AKAP95; A-kinase anchoring protein 95 (AKAP95)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      89995110..90035533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418427.1 → XP_047274383.1  DBIRD complex subunit ZNF326 isoform X1

    2. XM_047418429.1 → XP_047274385.1  DBIRD complex subunit ZNF326 isoform X2

    3. XM_047418437.1 → XP_047274393.1  DBIRD complex subunit ZNF326 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      89838332..89878758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336139.1 → XP_054192114.1  DBIRD complex subunit ZNF326 isoform X1

    2. XM_054336140.1 → XP_054192115.1  DBIRD complex subunit ZNF326 isoform X2

    3. XM_054336142.1 → XP_054192117.1  DBIRD complex subunit ZNF326 isoform X3

    4. XM_054336141.1 → XP_054192116.1  DBIRD complex subunit ZNF326 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BKZ1.2 GenPept UniProtKB/Swiss-Prot:Q5BKZ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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