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    Wsb1 WD repeat and SOCS box-containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303336, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Wsb1provided by RGD
    Official Full Name
    WD repeat and SOCS box-containing 1provided by RGD
    Primary source
    RGD:1307835
    See related
    EnsemblRapid:ENSRNOG00000012929 AllianceGenome:RGD:1307835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein K27-linked ubiquitination. Predicted to act upstream of or within protein aggregate center assembly. Predicted to be located in cytoplasm. Orthologous to human WSB1 (WD repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 343.8), Brain (RPKM 249.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wsb1 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (64700752..64717038, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (64202761..64219039, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (66586905..66602984, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene nitric oxide synthase 2, pseudogene 1 Neighboring gene galectin 9 Neighboring gene kinase suppressor of ras 1 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion like 2 Neighboring gene uncharacterized LOC120095152 Neighboring gene uncharacterized LOC102552371

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WSB1, as an E3 ligase, restrains myocardial ischemia-reperfusion injury by activating beta-catenin signaling via promoting GSK3beta ubiquitination.
      Title: WSB1, as an E3 ligase, restrains myocardial ischemia-reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination.
    2. High iodine intake had no discernible effects on USP20. Temporary increases in USP33 and USP19 mRNA levels were observed. The enzymes related to D2 ubiquitination change with prolonged high iodine intake. Increased D2 ubiquitination suppresses the activity of D2, causing a decrease in negative feedback of the hypothalamic-pituitary-thyroid axis.
      Title: Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary.
    3. Correlation between relative mRNA levels of WSB-1 and USP-33 in numerous tissues that do not express type 2 deiodinase(D2) suggests that these ubiquitin-related enzymes share additional substrates besides D2.
      Title: Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112712

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K27-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein aggregate center assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat and SOCS box-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025664.1 → NP_001020835.2  WD repeat and SOCS box-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001020835.2

      Status: VALIDATED

      Source sequence(s)
      BC098720
      UniProtKB/TrEMBL
      Q4KM78
      Conserved Domains (3) summary
      cd03746
      Location:140 → 179
      SOCS_WSB1_SWIP1; SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 ...
      sd00039
      Location:17 → 57
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:1 → 146
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001042561.1 → NP_001036026.1  WD repeat and SOCS box-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001036026.1

      Status: VALIDATED

      Source sequence(s)
      BC098720, CK473503, DY312839
      UniProtKB/TrEMBL
      A6HH82, B3DM89, F7FCT1
      Related
      ENSRNOP00000017949.4, ENSRNOT00000017949.7
      Conserved Domains (4) summary
      COG2319
      Location:38 → 382
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:135 → 388
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd03746
      Location:382 → 421
      SOCS_WSB1_SWIP1; SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 ...
      sd00039
      Location:174 → 212
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      64700752..64717038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269072.1 → XP_063125142.1  WD repeat and SOCS box-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      Q4KM78

    2. XM_017597304.2 → XP_017452793.1  WD repeat and SOCS box-containing protein 1 isoform X2

      Conserved Domains (4) summary
      COG2319
      Location:15 → 167
      WD40; WD40 repeat [General function prediction only]
      cd03746
      Location:159 → 198
      SOCS_WSB1_SWIP1; SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 ...
      sd00039
      Location:36 → 76
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:15 → 165
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_063269071.1 → XP_063125141.1  WD repeat and SOCS box-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6HH83
    Nucleotide Protein Strain
    Heading Accession and Version

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