Rab11fip4 RAB11 family interacting protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab11fip4provided by RGD
Official Full Name: RAB11 family interacting protein 4provided by RGD
Primary source: RGD:1305063
See related: EnsemblRapid:ENSRNOG00000014135 AllianceGenome:RGD:1305063
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305063
Summary: Predicted to enable protein homodimerization activity and small GTPase binding activity. Predicted to be involved in endocytic recycling and regulation of cytokinesis. Predicted to be located in endosome. Predicted to be active in cleavage furrow; cytoplasmic vesicle; and midbody. Orthologous to human RAB11FIP4 (RAB11 family interacting protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 213.6), Kidney (RPKM 78.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (65048070..65156086)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (64550109..64658123)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (66942363..67051672)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Rab11fip4 (e-PCR), detects polymorphism
- UniSTS:498250

RH137953 (e-PCR)
- UniSTS:220040

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural retina development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G1 to G0 transition	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cleavage furrow	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in recycling endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rab11 family-interacting protein 4

Names: RAB11 family interacting protein 4 (class II)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107023.1 → NP_001100493.1 rab11 family-interacting protein 4

See identical proteins and their annotated locations for NP_001100493.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A6HH90, D3ZHE5

Related

ENSRNOP00000018988.3, ENSRNOT00000018986.6

Conserved Domains (3) summary

pfam09457
Location:596 → 636

RBD-FIP; FIP domain

pfam13499
Location:21 → 78

EF-hand_7; EF-hand domain pair

cl03075
Location:428 → 512

GrpE; nucleotide exchange factor GrpE

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

65048070..65156086

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246903.5 → XP_006246965.1 rab11 family-interacting protein 4 isoform X1

Conserved Domains (3) summary

pfam09457
Location:573 → 613

RBD-FIP; FIP domain

pfam13499
Location:21 → 78

EF-hand_7; EF-hand domain pair

cl03075
Location:405 → 489

GrpE; nucleotide exchange factor GrpE
XM_008768017.3 → XP_008766239.1 rab11 family-interacting protein 4 isoform X2

Conserved Domains (2) summary

pfam09457
Location:516 → 556

RBD-FIP; FIP domain

cl03075
Location:348 → 432

GrpE; nucleotide exchange factor GrpE
XM_006246904.5 → XP_006246966.1 rab11 family-interacting protein 4 isoform X3

Conserved Domains (2) summary

pfam09457
Location:494 → 534

RBD-FIP; FIP domain

cl03075
Location:326 → 410

GrpE; nucleotide exchange factor GrpE
XM_063269073.1 → XP_063125143.1 rab11 family-interacting protein 4 isoform X4