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    Kifc2 kinesin family member C2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300053, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kifc2provided by RGD
    Official Full Name
    kinesin family member C2provided by RGD
    Primary source
    RGD:735021
    See related
    EnsemblRapid:ENSRNOG00000060123 AllianceGenome:RGD:735021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement and mitotic spindle assembly. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Orthologous to human KIFC2 (kinesin family member C2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 314.8), Kidney (RPKM 98.7) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kifc2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110261257..110269007)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108380634..108388364)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117722732..117730702)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Tmem276-zftraf1 readthrough Neighboring gene zinc finger TRAF type containing 1 Neighboring gene Transmembrane protein 276 Neighboring gene forkhead box H1 Neighboring gene protein phosphatase 1, regulatory subunit 16A Neighboring gene glutamic--pyruvic transaminase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of KIFC2, a neuronal kinesin superfamily member in mouse. Hanlon DW, et al. Neuron, 1997 Mar. PMID 9115737
    2. Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver. Nath S, et al. Mol Biol Cell, 2007 May. PMID 17360972, Free PMC Article
    3. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIFC2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198752.3 → NP_942047.2  kinesin-like protein KIFC2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      Q712J1
      Conserved Domains (2) summary
      smart00129
      Location:408 → 737
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01366
      Location:406 → 733
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      110261257..110269007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078824.2 → XP_038934752.1  kinesin-like protein KIFC2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K857, A6HSC1
      Related
      ENSRNOP00000074479.4, ENSRNOT00000085152.4
      Conserved Domains (1) summary
      cd01366
      Location:321 → 648
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    2. XM_063263314.1 → XP_063119384.1  kinesin-like protein KIFC2 isoform X4

    3. XM_063263313.1 → XP_063119383.1  kinesin-like protein KIFC2 isoform X2

    4. XM_039078825.2 → XP_038934753.1  kinesin-like protein KIFC2 isoform X3

      Conserved Domains (1) summary
      cl22853
      Location:406 → 578
      Motor_domain; Myosin and Kinesin motor domain

    5. XM_039078826.2 → XP_038934754.1  kinesin-like protein KIFC2 isoform X5

      Conserved Domains (1) summary
      cl22853
      Location:406 → 461
      Motor_domain; Myosin and Kinesin motor domain

    6. XM_039078828.2 → XP_038934756.1  kinesin-like protein KIFC2 isoform X6

      Conserved Domains (1) summary
      cl22853
      Location:406 → 461
      Motor_domain; Myosin and Kinesin motor domain

    7. XM_039078827.2 → XP_038934755.1  kinesin-like protein KIFC2 isoform X6

      Conserved Domains (1) summary
      cl22853
      Location:406 → 461
      Motor_domain; Myosin and Kinesin motor domain
    Nucleotide Protein Strain
    Heading Accession and Version

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