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    Lto1 LTO1 maturation factor of ABCE1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309136, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lto1provided by RGD
    Official Full Name
    LTO1 maturation factor of ABCE1provided by RGD
    Primary source
    RGD:1304637
    See related
    EnsemblRapid:ENSRNOG00000020903 AllianceGenome:RGD:1304637
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Oraov1
    Summary
    Predicted to be involved in gene expression; ribosomal large subunit biogenesis; and telomere maintenance. Orthologous to human LTO1 (LTO1 maturation factor of ABCE1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 45.3), Lung (RPKM 43.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lto1 in Genome Data Viewer
    Location:
    1q42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (209502900..209510237)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (200074247..200080951)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (218075995..218082700)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485204 Neighboring gene fibroblast growth factor 19 Neighboring gene brain cytoplasmic RNA 1 Neighboring gene ribosomal protein S10, pseudogene 18 Neighboring gene cyclin D1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome. Zhai C, et al. Oncogene, 2014 Jan 23. PMID 23318452
    2. The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion. Paul VD, et al. Elife, 2015 Jul 16. PMID 26182403, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein maturation by [4Fe-4S] cluster transfer ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein LTO1 homolog
    Names
    LTO1, ABCE1 maturation factor
    oral cancer overexpressed 1
    oral cancer-overexpressed protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107565.1 → NP_001101035.1  protein LTO1 homolog

      See identical proteins and their annotated locations for NP_001101035.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A0A8I6A2Q3, A6HYI1, A6HYI3
      Conserved Domains (1) summary
      pfam09811
      Location:107 → 145
      Yae1_N; Essential protein Yae1, N terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      209502900..209510237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264152.1 → XP_063120222.1  protein LTO1 homolog isoform X1

    2. XM_063264161.1 → XP_063120231.1  protein LTO1 homolog isoform X4

    3. XM_017589240.3 → XP_017444729.2  protein LTO1 homolog isoform X2

      Related
      ENSRNOP00000085622.2, ENSRNOT00000114678.2

    4. XM_017589242.3 → XP_017444731.2  protein LTO1 homolog isoform X5

    5. XM_017589241.3 → XP_017444730.2  protein LTO1 homolog isoform X3

    6. XM_039079182.2 → XP_038935110.2  protein LTO1 homolog isoform X6

    7. XM_063264171.1 → XP_063120241.1  protein LTO1 homolog isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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