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    Lrrc14 leucine rich repeat containing 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500900, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Lrrc14provided by RGD
    Official Full Name
    leucine rich repeat containing 14provided by RGD
    Primary source
    RGD:1560202
    See related
    EnsemblRapid:ENSRNOG00000016128 AllianceGenome:RGD:1560202
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable kinase binding activity. Predicted to be involved in negative regulation of NF-kappaB transcription factor activity and negative regulation of toll-like receptor signaling pathway. Predicted to be active in cytoplasm. Orthologous to human LRRC14 (leucine rich repeat containing 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 65.6), Kidney (RPKM 62.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc14 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110311384..110317757)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108430755..108437118)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117773219..117779555)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glutamic--pyruvic transaminase Neighboring gene major facilitator superfamily domain containing 3 Neighboring gene RecQ like helicase 4 Neighboring gene leucine rich repeat containing 24 Neighboring gene similar to human chromosome 8 open reading frame 82 Neighboring gene Rho GTPase activating protein 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex. Wu C, et al. Exp Cell Res, 2016 Sep 10. PMID 27426725
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108882

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024354.1 → NP_001019525.1  leucine-rich repeat-containing protein 14 isoform 2

      See identical proteins and their annotated locations for NP_001019525.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092583
      UniProtKB/Swiss-Prot
      Q569B5
      UniProtKB/TrEMBL
      A0A8L2UJL0
      Conserved Domains (3) summary
      sd00031
      Location:311 → 337
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:286 → 309
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:221 → 414
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. NM_001401224.1 → NP_001388153.1  leucine-rich repeat-containing protein 14 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JUP6, A0A8L2UJL0
      Related
      ENSRNOP00000069176.1, ENSRNOT00000077562.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      110311384..110317757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264131.1 → XP_063120201.1  leucine-rich repeat-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZT2, A0A8L2UJL0

    2. XM_006241862.5 → XP_006241924.1  leucine-rich repeat-containing protein 14 isoform X3

      See identical proteins and their annotated locations for XP_006241924.1

      UniProtKB/Swiss-Prot
      Q569B5
      UniProtKB/TrEMBL
      A0A8L2UJL0
      Conserved Domains (3) summary
      sd00031
      Location:311 → 337
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:286 → 309
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:221 → 414
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    3. XM_039079759.2 → XP_038935687.1  leucine-rich repeat-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UJL0
      Conserved Domains (3) summary
      sd00031
      Location:354 → 380
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:329 → 352
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:264 → 457
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    4. XM_063264130.1 → XP_063120200.1  leucine-rich repeat-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZT2, A0A8L2UJL0
      Related
      ENSRNOP00000083734.1, ENSRNOT00000097197.2

    5. XM_063264128.1 → XP_063120198.1  leucine-rich repeat-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZT2, A0A8L2UJL0

    6. XM_063264132.1 → XP_063120202.1  leucine-rich repeat-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZT2, A0A8L2UJL0

    7. XM_039079758.2 → XP_038935686.1  leucine-rich repeat-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UJL0
      Related
      ENSRNOP00000098700.1, ENSRNOT00000173835.1
      Conserved Domains (3) summary
      sd00031
      Location:354 → 380
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:329 → 352
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:264 → 457
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    8. XM_063264133.1 → XP_063120203.1  leucine-rich repeat-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZT2, A0A8L2UJL0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q569B5.1 GenPept UniProtKB/Swiss-Prot:Q569B5

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