U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mak male germ cell-associated kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25677, updated on 10-Jul-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Makprovided by RGD
    Official Full Name
    male germ cell-associated kinaseprovided by RGD
    Primary source
    RGD:3036
    See related
    EnsemblRapid:ENSRNOG00000015101 AllianceGenome:RGD:3036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Predicted to be involved in several processes, including cilium organization; photoreceptor cell maintenance; and protein autophosphorylation. Predicted to act upstream of or within negative regulation of non-motile cilium assembly. Predicted to be located in several cellular components, including ciliary tip; cytoskeleton; and photoreceptor cell cilium. Predicted to be active in cilium; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 62. Orthologous to human MAK (male germ cell associated kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 86.6) and Lung (RPKM 12.4) See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Mak in Genome Data Viewer
    Location:
    17p12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (23889417..23936857)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (23683753..23731125)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (21531651..21567742)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene synaptonemal complex protein 2-like Neighboring gene glial cells missing transcription factor 2 Neighboring gene uncharacterized LOC134482840 Neighboring gene transmembrane protein 14C Neighboring gene PAK1 interacting protein 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa. Tucker BA, et al. Proc Natl Acad Sci U S A, 2011 Aug 23. PMID 21825139, Free PMC Article
    2. Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells. Ma AH, et al. Cancer Res, 2006 Sep 1. PMID 16951154
    3. Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells. Xia L, et al. J Biol Chem, 2002 Sep 20. PMID 12084720
    4. A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis. Matsushime H, et al. Mol Cell Biol, 1990 May. PMID 2183027, Free PMC Article
    5. Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1. Wang LY, et al. Oncogene, 2012 Jun 14. PMID 21986944, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC93585

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of non-motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in photoreceptor cell maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within photoreceptor cell maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in photoreceptor cell maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in photoreceptor connecting cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor connecting cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor inner segment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor outer segment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine/threonine-protein kinase MAK
    NP_037268.2
    XP_038951317.1
    XP_038951319.1
    XP_038951321.1
    XP_038951322.1
    XP_038951323.1
    XP_038951324.1
    XP_063132181.1
    XP_063132182.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013136.3 → NP_037268.2  serine/threonine-protein kinase MAK

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      G3V7Y4, P20793, Q6AYW0
      UniProtKB/TrEMBL
      A0A8I6G9U0
      Conserved Domains (1) summary
      cd07830
      Location:4 → 284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      23889417..23936857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276111.1 → XP_063132181.1  serine/threonine-protein kinase MAK isoform X2

      UniProtKB/TrEMBL
      A0A8I6G9U0

    2. XM_063276112.1 → XP_063132182.1  serine/threonine-protein kinase MAK isoform X4

      UniProtKB/TrEMBL
      A0A8I6AB71

    3. XM_039095389.2 → XP_038951317.1  serine/threonine-protein kinase MAK isoform X1

      UniProtKB/Swiss-Prot
      G3V7Y4, P20793, Q6AYW0
      UniProtKB/TrEMBL
      A0A8I6G9U0
      Related
      ENSRNOP00000020672.4, ENSRNOT00000020672.9
      Conserved Domains (1) summary
      cd07830
      Location:4 → 284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    4. XM_039095395.2 → XP_038951323.1  serine/threonine-protein kinase MAK isoform X4

      UniProtKB/TrEMBL
      A0A8I6AB71
      Related
      ENSRNOP00000079083.1, ENSRNOT00000107200.2
      Conserved Domains (1) summary
      cd07830
      Location:4 → 284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    5. XM_039095396.1 → XP_038951324.1  serine/threonine-protein kinase MAK isoform X5

      UniProtKB/TrEMBL
      A0A8I6G9U0
      Related
      ENSRNOP00000084056.2, ENSRNOT00000105813.2
      Conserved Domains (1) summary
      cd07830
      Location:4 → 284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    6. XM_039095393.1 → XP_038951321.1  serine/threonine-protein kinase MAK isoform X2

      UniProtKB/TrEMBL
      A0A8I6G9U0
      Conserved Domains (1) summary
      cd07830
      Location:4 → 284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    7. XM_039095391.2 → XP_038951319.1  serine/threonine-protein kinase MAK isoform X1

      UniProtKB/Swiss-Prot
      G3V7Y4, P20793, Q6AYW0
      UniProtKB/TrEMBL
      A0A8I6G9U0
      Conserved Domains (1) summary
      cd07830
      Location:4 → 284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    8. XM_039095394.2 → XP_038951322.1  serine/threonine-protein kinase MAK isoform X3

      UniProtKB/TrEMBL
      A0A8I6G9U0
      Conserved Domains (1) summary
      cd07830
      Location:1 → 250
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20793.2 GenPept UniProtKB/Swiss-Prot:P20793

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools