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    Ccnt2 cyclin T2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304758, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ccnt2provided by RGD
    Official Full Name
    cyclin T2provided by RGD
    Primary source
    RGD:1309205
    See related
    EnsemblRapid:ENSRNOG00000017113 AllianceGenome:RGD:1309205
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including 7SK snRNA binding activity; cyclin-dependent protein serine/threonine kinase activator activity; and enzyme binding activity. Predicted to be involved in several processes, including early viral transcription; late viral transcription; and positive regulation of transcription elongation by RNA polymerase II. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Orthologous to human CCNT2 (cyclin T2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 118.2), Lung (RPKM 114.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccnt2 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (41804007..41845641)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (39251573..39293172)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (44475959..44516892)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 163 Neighboring gene aminocarboxymuconate semialdehyde decarboxylase Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene RAB3 GTPase activating protein catalytic subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Restoration of NRF2 attenuates myocardial ischemia reperfusion injury through mediating microRNA-29a-3p/CCNT2 axis. Tian R, et al. Biofactors, 2021 May. PMID 33600051
    2. Activation and function of murine Cyclin T2A and Cyclin T2B during skeletal muscle differentiation. Marchesi I, et al. J Cell Biochem, 2013 Mar. PMID 23060074
    3. HSV-1 stimulation-related protein HSRG1 inhibits viral gene transcriptional elongation by interacting with Cyclin T2. Wu W, et al. Sci China Life Sci, 2011 Apr. PMID 21509660
    4. Pkn is a novel partner of cyclin T2a in muscle differentiation. Cottone G, et al. J Cell Physiol, 2006 Apr. PMID 16331689
    5. Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb. Kurosu T, et al. Gene, 2004 Dec 8. PMID 15563843

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Restoration of NRF2 attenuates myocardial ischemia reperfusion injury through mediating microRNA-29a-3p/CCNT2 axis.
      Title: Restoration of NRF2 attenuates myocardial ischemia reperfusion injury through mediating microRNA-29a-3p/CCNT2 axis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 7SK snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in early viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in late viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription, elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin/CDK positive transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-T2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107171.1 → NP_001100641.1  cyclin-T2

      See identical proteins and their annotated locations for NP_001100641.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473958
      UniProtKB/TrEMBL
      A6IBW0, D3ZGL6
      Related
      ENSRNOP00000024602.5, ENSRNOT00000024602.9
      Conserved Domains (2) summary
      COG5333
      Location:8 → 216
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
      cd00043
      Location:36 → 108
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      41804007..41845641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249686.5 → XP_006249748.1  cyclin-T2 isoform X2

      See identical proteins and their annotated locations for XP_006249748.1

      UniProtKB/TrEMBL
      A9CMA7
      Related
      ENSRNOP00000085308.2, ENSRNOT00000096878.2
      Conserved Domains (2) summary
      COG5333
      Location:8 → 216
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
      cd00043
      Location:36 → 108
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    2. XM_063272276.1 → XP_063128346.1  cyclin-T2 isoform X1

    3. XM_063272277.1 → XP_063128347.1  cyclin-T2 isoform X3

    4. XM_017598786.2 → XP_017454275.1  cyclin-T2 isoform X4

      Conserved Domains (1) summary
      cl40454
      Location:18 → 115
      CYCLIN_SF; Cyclin box fold superfamily

    5. XM_063272278.1 → XP_063128348.1  cyclin-T2 isoform X4

    6. XM_017598787.3 → XP_017454276.1  cyclin-T2 isoform X5

      Conserved Domains (1) summary
      cl40454
      Location:1 → 84
      CYCLIN_SF; Cyclin box fold superfamily

    7. XM_039090688.2 → XP_038946616.1  cyclin-T2 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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