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    Ctnnal1 catenin alpha-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298019, updated on 9-Jul-2024

    Summary

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    Official Symbol
    Ctnnal1provided by RGD
    Official Full Name
    catenin alpha-like 1provided by RGD
    Primary source
    RGD:1311434
    See related
    Ensembl:ENSRNOG00000010593 AllianceGenome:RGD:1311434
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Catnal1
    Summary
    Predicted to enable actin filament binding activity and cadherin binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within Rho protein signal transduction. Predicted to be located in cytosol. Orthologous to human CTNNAL1 (catenin alpha like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 105.0), Uterus (RPKM 100.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ctnnal1 in Genome Data Viewer
    Location:
    5q24
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (76309546..76375869, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (71514340..71569431, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (73561249..73621070, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 1 Neighboring gene actin binding transcription modulator Neighboring gene transmembrane protein 245 Neighboring gene microRNA 32 Neighboring gene ferric-chelate reductase 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. Park B, et al. J Biol Chem, 2002 Nov 22. PMID 12270917
    2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-catulin
    Names
    catenin (cadherin associated protein), alpha-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106649.1 → NP_001100119.1  alpha-catulin

      See identical proteins and their annotated locations for NP_001100119.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474039
      UniProtKB/TrEMBL
      A0A8I6GEV6, A6KDR8, D4A739
      Related
      ENSRNOP00000014888.4, ENSRNOT00000014888.6
      Conserved Domains (1) summary
      pfam01044
      Location:91 → 674
      Vinculin; Vinculin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      76309546..76375869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287306.1 → XP_063143376.1  alpha-catulin isoform X1

      UniProtKB/TrEMBL
      A0A8I6GEV6

    2. XM_006238177.5 → XP_006238239.1  alpha-catulin isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y1A6, A0A8I6GEV6
      Related
      ENSRNOP00000077198.1, ENSRNOT00000106413.2
      Conserved Domains (1) summary
      pfam01044
      Location:51 → 634
      Vinculin; Vinculin family

    3. XM_039109442.2 → XP_038965370.1  alpha-catulin isoform X3

      Conserved Domains (1) summary
      pfam01044
      Location:4 → 498
      Vinculin; Vinculin family

    4. XM_039109443.1 → XP_038965371.1  alpha-catulin isoform X4

      Conserved Domains (1) summary
      pfam01044
      Location:54 → 411
      Vinculin; Vinculin family
    Nucleotide Protein Strain
    Heading Accession and Version

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