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    CEP192 centrosomal protein 192 [ Homo sapiens (human) ]

    Gene ID: 55125, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CEP192provided by HGNC
    Official Full Name
    centrosomal protein 192provided by HGNC
    Primary source
    HGNC:HGNC:25515
    See related
    Ensembl:ENSG00000101639 MIM:616426; AllianceGenome:HGNC:25515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PPP1R62
    Summary
    Enables phosphatase binding activity. Involved in centrosome-templated microtubule nucleation; mitotic spindle assembly; and protein localization to centrosome. Located in centriole and centrosome. Part of procentriole and procentriole replication complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 8.2), gall bladder (RPKM 6.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CEP192 in Genome Data Viewer
    Location:
    18p11.21
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (12991362..13125036)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (13154097..13287771)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (12991361..13125035)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 933 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9324 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:12948589-12949190 Neighboring gene SEH1 like nucleoporin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:12989680-12990292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9328 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:13061945-13062156 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:13068543-13069742 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13135678-13136257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13136258-13136836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13113 Neighboring gene Sharpr-MPRA regulatory region 6122 Neighboring gene WD repeat domain 89 pseudogene Neighboring gene MRT4 homolog, ribosome maturation factor pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Recruitment of PP1 to the centrosomal scaffold protein CEP192. Nasa I, et al. Biochem Biophys Res Commun, 2017 Mar 18. PMID 28188792, Free PMC Article
    2. Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly. Chinen T, et al. J Cell Biol, 2021 Feb 1. PMID 33443571, Free PMC Article
    3. Cep192 controls the balance of centrosome and non-centrosomal microtubules during interphase. O'Rourke BP, et al. PLoS One, 2014. PMID 24971877, Free PMC Article
    4. CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma. Liu Y, et al. Front Immunol, 2022. PMID 36238304, Free PMC Article
    5. Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192. Guo J, et al. HGG Adv, 2024 Jan 11. PMID 37981762, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.
      Title: Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.
    2. CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma.
      Title: CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma.
    3. Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.
      Title: Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.
    4. Identification of genes in hepatocellular carcinoma induced by non-alcoholic fatty liver disease.
      Title: Identification of genes in hepatocellular carcinoma induced by non-alcoholic fatty liver disease.
    5. induced FBXL13 expression downregulates centrosomal gamma-tubulin and disrupts centrosomal microtubule arrays. In addition, depletion of FBXL13 induces high levels of CEP192 and gamma-tubulin at the centrosomes with the consequence of defects in cell motility.
      Title: FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.
    6. Study shows that the interaction between Cep295 and Cep192 seems to be crucial for the integrity of centriole structure and also for daughter-to-mother centriole conversion.
      Title: Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.
    7. Here we demonstrate that CEP192 also recruits the type one protein phosphatase (PP1) via a highly conserved KHVTF docking motif.
      Title: Recruitment of PP1 to the centrosomal scaffold protein CEP192.
    8. Interphase cells depleted of Cep192 display significantly higher levels of centrosome-associated Pericentrin while overexpression of Cep192 reduces the levels of centrosomal Pericentrin.
      Title: Cep192 controls the balance of centrosome and non-centrosomal microtubules during interphase.
    9. Plk1 promotes centrosome-based bipolar spindle formation by forming two functionally nonredundant complexes with Cep192.
      Title: Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold, Cep192, in the Regulation of Bipolar Spindle Formation.
    10. Study identifies a Cep192-organized signaling cascade that underlies both centrosome maturation and bipolar spindle assembly.
      Title: The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in centriole replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome-templated microtubule nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in pericentriolar material IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in procentriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of procentriole replication complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centrosomal protein of 192 kDa
    Names
    192 kDa centrosomal protein
    centrosomal protein 192kDa
    cep192/SPD-2
    protein phosphatase 1, regulatory subunit 62

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032142.4 → NP_115518.3  centrosomal protein of 192 kDa

      Status: VALIDATED

      Source sequence(s)
      AB046789, AK096548, AL833494, BC144481, BX648232, DB079620
      Consensus CDS
      CCDS32792.2
      UniProtKB/Swiss-Prot
      A0A060A9S4, B7ZMF0, E9PF99, Q8TEP8, Q8WYT8, Q9H0F4, Q9NW27
      UniProtKB/TrEMBL
      K7ENP4
      Related
      ENSP00000427550.1, ENST00000506447.5
      Conserved Domains (1) summary
      pfam08626
      Location:1677 → 1767
      TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      12991362..13125036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722326.4 → XP_006722389.1  centrosomal protein of 192 kDa isoform X2

      UniProtKB/TrEMBL
      K7ENP4
      Conserved Domains (1) summary
      cl13764
      Location:1660 → 1724
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    2. XM_005258107.4 → XP_005258164.1  centrosomal protein of 192 kDa isoform X1

      UniProtKB/TrEMBL
      K7ENP4
      Conserved Domains (1) summary
      cl13764
      Location:1660 → 1724
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    3. XM_047437562.1 → XP_047293518.1  centrosomal protein of 192 kDa isoform X3

    4. XM_047437564.1 → XP_047293520.1  centrosomal protein of 192 kDa isoform X8

    5. XM_011525673.3 → XP_011523975.1  centrosomal protein of 192 kDa isoform X4

      UniProtKB/TrEMBL
      K7ENP4
      Conserved Domains (1) summary
      cl13764
      Location:1660 → 1727
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    6. XM_047437565.1 → XP_047293521.1  centrosomal protein of 192 kDa isoform X9

    7. XM_047437563.1 → XP_047293519.1  centrosomal protein of 192 kDa isoform X5

    8. XM_047437566.1 → XP_047293522.1  centrosomal protein of 192 kDa isoform X10

    9. XM_005258109.4 → XP_005258166.1  centrosomal protein of 192 kDa isoform X6

      UniProtKB/TrEMBL
      K7ENP4
      Conserved Domains (1) summary
      cl13764
      Location:1590 → 1654
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    10. XM_047437567.1 → XP_047293523.1  centrosomal protein of 192 kDa isoform X11

    11. XM_006722327.4 → XP_006722390.1  centrosomal protein of 192 kDa isoform X7

      UniProtKB/TrEMBL
      K7ENP4
      Related
      ENSP00000317156.9, ENST00000325971.12
      Conserved Domains (1) summary
      cl13764
      Location:1590 → 1654
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    12. XM_047437568.1 → XP_047293524.1  centrosomal protein of 192 kDa isoform X13

    13. XM_047437569.1 → XP_047293525.1  centrosomal protein of 192 kDa isoform X14

    14. XM_006722330.4 → XP_006722393.1  centrosomal protein of 192 kDa isoform X20

      UniProtKB/TrEMBL
      A0A0A0MR42
      Conserved Domains (1) summary
      cl13764
      Location:1321 → 1385
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    15. XM_017025804.2 → XP_016881293.1  centrosomal protein of 192 kDa isoform X21

      UniProtKB/TrEMBL
      A0A0A0MR42

    16. XM_047437575.1 → XP_047293531.1  centrosomal protein of 192 kDa isoform X22

    17. XM_047437571.1 → XP_047293527.1  centrosomal protein of 192 kDa isoform X16

    18. XM_047437573.1 → XP_047293529.1  centrosomal protein of 192 kDa isoform X18

    19. XM_047437570.1 → XP_047293526.1  centrosomal protein of 192 kDa isoform X15

    20. XM_047437572.1 → XP_047293528.1  centrosomal protein of 192 kDa isoform X17

    21. XM_047437576.1 → XP_047293532.1  centrosomal protein of 192 kDa isoform X23

    22. XM_047437579.1 → XP_047293535.1  centrosomal protein of 192 kDa isoform X26

    23. XM_011525675.4 → XP_011523977.2  centrosomal protein of 192 kDa isoform X12

      UniProtKB/TrEMBL
      K7ENP4
      Conserved Domains (1) summary
      pfam08626
      Location:1587 → 1677
      TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit

    24. XM_047437574.1 → XP_047293530.1  centrosomal protein of 192 kDa isoform X19

      Related
      ENSP00000423147.1, ENST00000510237.5

    25. XM_047437577.1 → XP_047293533.1  centrosomal protein of 192 kDa isoform X24

      Related
      ENSP00000467038.1, ENST00000511820.6

    26. XM_047437578.1 → XP_047293534.1  centrosomal protein of 192 kDa isoform X25

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      13154097..13287771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318718.1 → XP_054174693.1  centrosomal protein of 192 kDa isoform X2

    2. XM_054318717.1 → XP_054174692.1  centrosomal protein of 192 kDa isoform X1

    3. XM_054318719.1 → XP_054174694.1  centrosomal protein of 192 kDa isoform X3

    4. XM_054318724.1 → XP_054174699.1  centrosomal protein of 192 kDa isoform X8

    5. XM_054318720.1 → XP_054174695.1  centrosomal protein of 192 kDa isoform X4

    6. XM_054318725.1 → XP_054174700.1  centrosomal protein of 192 kDa isoform X9

    7. XM_054318721.1 → XP_054174696.1  centrosomal protein of 192 kDa isoform X5

    8. XM_054318726.1 → XP_054174701.1  centrosomal protein of 192 kDa isoform X10

    9. XM_054318722.1 → XP_054174697.1  centrosomal protein of 192 kDa isoform X6

    10. XM_054318727.1 → XP_054174702.1  centrosomal protein of 192 kDa isoform X11

    11. XM_054318723.1 → XP_054174698.1  centrosomal protein of 192 kDa isoform X7

    12. XM_054318729.1 → XP_054174704.1  centrosomal protein of 192 kDa isoform X13

    13. XM_054318730.1 → XP_054174705.1  centrosomal protein of 192 kDa isoform X14

    14. XM_054318736.1 → XP_054174711.1  centrosomal protein of 192 kDa isoform X20

    15. XM_054318737.1 → XP_054174712.1  centrosomal protein of 192 kDa isoform X21

    16. XM_054318738.1 → XP_054174713.1  centrosomal protein of 192 kDa isoform X22

    17. XM_054318732.1 → XP_054174707.1  centrosomal protein of 192 kDa isoform X16

    18. XM_054318734.1 → XP_054174709.1  centrosomal protein of 192 kDa isoform X18

    19. XM_054318731.1 → XP_054174706.1  centrosomal protein of 192 kDa isoform X15

    20. XM_054318733.1 → XP_054174708.1  centrosomal protein of 192 kDa isoform X17

    21. XM_054318739.1 → XP_054174714.1  centrosomal protein of 192 kDa isoform X23

    22. XM_054318742.1 → XP_054174717.1  centrosomal protein of 192 kDa isoform X26

    23. XM_054318728.1 → XP_054174703.1  centrosomal protein of 192 kDa isoform X12

    24. XM_054318735.1 → XP_054174710.1  centrosomal protein of 192 kDa isoform X19

    25. XM_054318740.1 → XP_054174715.1  centrosomal protein of 192 kDa isoform X24

    26. XM_054318741.1 → XP_054174716.1  centrosomal protein of 192 kDa isoform X25

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018069.2: Suppressed sequence

      Description
      NM_018069.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TEP8.3 GenPept UniProtKB/Swiss-Prot:Q8TEP8

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