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    ZYX zyxin [ Homo sapiens (human) ]

    Gene ID: 7791, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZYXprovided by HGNC
    Official Full Name
    zyxinprovided by HGNC
    Primary source
    HGNC:HGNC:13200
    See related
    Ensembl:ENSG00000159840 MIM:602002; AllianceGenome:HGNC:13200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESP-2; HED-2
    Summary
    Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 122.6), lung (RPKM 100.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZYX in Genome Data Viewer
    Location:
    7q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (143381345..143391111)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (144736772..144746538)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143078438..143088204)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene FAM131B antisense RNA 1 Neighboring gene family with sequence similarity 131 member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26792 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143077234-143078134 Neighboring gene FAM131B antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:143088659-143089259 Neighboring gene Sharpr-MPRA regulatory region 10434 Neighboring gene microRNA 6892 Neighboring gene Sharpr-MPRA regulatory region 2529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:143101922-143102436 Neighboring gene EPH receptor A1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143106021-143106633 Neighboring gene EPHA1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 12322 Neighboring gene taste 2 receptor member 62 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner. Hirata H, et al. J Cell Sci, 2008 Sep 1. PMID 18682496
    2. Role of zyxin in differential cell spreading and proliferation of melanoma cells and melanocytes. van der Gaag EJ, et al. J Invest Dermatol, 2002 Feb. PMID 11841540
    3. Matrix density alters zyxin phosphorylation, which limits peripheral process formation and extension in endothelial cells invading 3D collagen matrices. Abbey CA, et al. Matrix Biol, 2014 Sep. PMID 25038525
    4. A zyxin-nectin interaction facilitates zyxin localization to cell-cell adhesions. Gregory Call S, et al. Biochem Biophys Res Commun, 2011 Nov 25. PMID 22056563
    5. Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins. Siddiqui MQ, et al. Int J Mol Sci, 2021 Mar 5. PMID 33808029, Free PMC Article

    See all (174) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.
      Title: Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.
    2. Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway.
      Title: Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway.
    3. Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-beta Signaling Pathways via Integrins.
      Title: Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-β Signaling Pathways via Integrins.
    4. Expression of Zyxin in Non-Small Cell Lung Cancer-A Preliminary Study.
      Title: Expression of Zyxin in Non-Small Cell Lung Cancer-A Preliminary Study.
    5. Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
      Title: Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
    6. Force-responsive Zyxin modulation in periodontal ligament cells is regulated by YAP rather than TAZ.
      Title: Force-responsive Zyxin modulation in periodontal ligament cells is regulated by YAP rather than TAZ.
    7. Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins.
      Title: Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins.
    8. Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival.
      Title: Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival.
    9. Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme.
      Title: Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme.
    10. Zyxin promotes MAVS-mediated IFNB1 promoter activation.
      Title: Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response.
    Submit: New GeneRIF Correction See all GeneRIFs (42)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zyxin (ZYX) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein zyxin. HIV-1 Nef co-localizes with zyxin in the cortical regions of human podocyte PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cellular response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in focal adhesion HDA PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zyxin
    Names
    zyxin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010972.2 → NP_001010972.1  zyxin isoform 1

      See identical proteins and their annotated locations for NP_001010972.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC008743, BC009360, BU844538
      Consensus CDS
      CCDS5883.1
      UniProtKB/Swiss-Prot
      A4D2G6, B4DQX7, Q15942, Q6I9S4
      UniProtKB/TrEMBL
      H0Y2Y8
      Conserved Domains (3) summary
      cd09349
      Location:351 → 437
      LIM1_Zyxin; The first LIM domain of Zyxin
      cd09435
      Location:504 → 570
      LIM3_Zyxin; The third LIM domain of Zyxin
      cl02475
      Location:444 → 503
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. NM_001362783.2 → NP_001349712.1  zyxin isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK298925, BC008743, BM857080
      UniProtKB/TrEMBL
      H0Y2Y8
      Conserved Domains (3) summary
      cd09435
      Location:473 → 539
      LIM3_Zyxin; The third LIM domain of Zyxin
      cl02475
      Location:320 → 406
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl25764
      Location:170 → 334
      PAT1; Topoisomerase II-associated protein PAT1

    3. NM_003461.5 → NP_003452.1  zyxin isoform 1

      See identical proteins and their annotated locations for NP_003452.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC008743
      Consensus CDS
      CCDS5883.1
      UniProtKB/Swiss-Prot
      A4D2G6, B4DQX7, Q15942, Q6I9S4
      UniProtKB/TrEMBL
      H0Y2Y8
      Related
      ENSP00000324422.5, ENST00000322764.10
      Conserved Domains (3) summary
      cd09349
      Location:351 → 437
      LIM1_Zyxin; The first LIM domain of Zyxin
      cd09435
      Location:504 → 570
      LIM3_Zyxin; The third LIM domain of Zyxin
      cl02475
      Location:444 → 503
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      143381345..143391111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420817.1 → XP_047276773.1  zyxin isoform X1

      Related
      ENSP00000346417.4, ENST00000354434.8

    2. XM_047420818.1 → XP_047276774.1  zyxin isoform X2

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654714.1 Reference GRCh38.p14 PATCHES

      Range
      709..10475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332171.1 → XP_054188146.1  zyxin isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      144736772..144746538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358968.1 → XP_054214943.1  zyxin isoform X1

    2. XM_054358969.1 → XP_054214944.1  zyxin isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15942.1 GenPept UniProtKB/Swiss-Prot:Q15942

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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