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    GAS1 growth arrest specific 1 [ Homo sapiens (human) ]

    Gene ID: 2619, updated on 28-Oct-2024

    Summary

    Official Symbol
    GAS1provided by HGNC
    Official Full Name
    growth arrest specific 1provided by HGNC
    Primary source
    HGNC:HGNC:4165
    See related
    Ensembl:ENSG00000180447 MIM:139185; AllianceGenome:HGNC:4165
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]
    Orthologs
    NEW
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    Genomic context

    See GAS1 in Genome Data Viewer
    Location:
    9q21.33
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (86944362..86947506, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (99095595..99098739, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (89559277..89562421, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2834 Neighboring gene uncharacterized LOC124902195 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:89406557-89407756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:89453773-89454274 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:89555636-89556336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19999 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108378 Neighboring gene GAS1 adjacent regulatory RNA Neighboring gene long intergenic non-protein coding RNA 2893 Neighboring gene cell division cycle 20 pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables oxysterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in developmental growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of protein processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of ER to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    growth arrest-specific protein 1
    Names
    GAS-1
    Growth arrest-specific gene-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032760.1 RefSeqGene

      Range
      4684..7828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002048.3NP_002039.2  growth arrest-specific protein 1 precursor

      See identical proteins and their annotated locations for NP_002039.2

      Status: REVIEWED

      Source sequence(s)
      AL158149, BC132682, BM661942, L13698
      Consensus CDS
      CCDS6674.1
      UniProtKB/Swiss-Prot
      B9EGM4, P54826, Q6B086
      Related
      ENSP00000298743.7, ENST00000298743.9
      Conserved Domains (1) summary
      smart00907
      Location:48143
      GDNF; GDNF/GAS1 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      86944362..86947506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      99095595..99098739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)