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    TRADD TNFRSF1A associated via death domain [ Homo sapiens (human) ]

    Gene ID: 8717, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TRADDprovided by HGNC
    Official Full Name
    TNFRSF1A associated via death domainprovided by HGNC
    Primary source
    HGNC:HGNC:12030
    See related
    Ensembl:ENSG00000102871 MIM:603500; AllianceGenome:HGNC:12030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Hs.89862
    Summary
    The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in stomach (RPKM 7.8), spleen (RPKM 7.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRADD in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67154185..67159909, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72948477..72954201, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67188088..67193812, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7578 Neighboring gene core-binding factor subunit beta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67142676-67143418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67143419-67144160 Neighboring gene phagophore assembly factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7581 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67189519-67190420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7584 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67195788-67196300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67196374-67197322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67197323-67198271 Neighboring gene Sharpr-MPRA regulatory region 11796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7588 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67206328-67206491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67207408-67208330 Neighboring gene F-box and leucine rich repeat protein 8 Neighboring gene heat shock transcription factor 4 Neighboring gene microtubule associated tyrosine carboxypeptidase 1 Neighboring gene nucleolar protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The NMR structure of the TRADD death domain, a key protein in the TNF signaling pathway. Tsao DH, et al. J Biomol NMR, 2007 Dec. PMID 17922260
    2. Nuclear TRADD prevents DNA damage-mediated death by facilitating non-homologous end-joining repair. Koo GB, et al. Sci Rep, 2017 Jun 13. PMID 28611389, Free PMC Article
    3. Identification of TRADD as a potential biomarker in human uterine leiomyoma through iTRAQ based proteomic profiling. Liu Y, et al. Mol Cell Probes, 2017 Dec. PMID 28698006
    4. Structure of the C-terminal domain of TRADD reveals a novel fold in the death domain superfamily. Zhang N, et al. Sci Rep, 2017 Aug 1. PMID 28765645, Free PMC Article
    5. Assignment of TRADD to human chromosome band 16q22 by in situ hybridization. Scheuerpflug CG, et al. Cytogenet Cell Genet, 2001. PMID 11435712

    See all (171) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseases.
      Title: Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseases.
    2. RIPK1 and TRADD Regulate TNF-Induced Signaling and Ripoptosome Formation.
      Title: RIPK1 and TRADD Regulate TNF-Induced Signaling and Ripoptosome Formation.
    3. Structural basis of NF-kappaB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains.
      Title: Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains.
    4. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.
      Title: Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.
    5. Coronin 1B regulates the TNFalpha-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD.
      Title: Coronin 1B regulates the TNFα-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD.
    6. SNHG9, delivered by adipocyte-derived exosomes, alleviates inflammation and apoptosis of endothelial cells through suppressing TRADD expression.
      Title: SNHG9, delivered by adipocyte-derived exosomes, alleviates inflammation and apoptosis of endothelial cells through suppressing TRADD expression.
    7. The TRADD C-terminal death domain comprises two super-secondary structures, an all-helix Greek key motif and a beta-hairpin motif flanked by two alpha helices, which make it unique among all known C-terminal death domain structures.
      Title: Structure of the C-terminal domain of TRADD reveals a novel fold in the death domain superfamily.
    8. Translocation of TRADD to DSBs into the nucleus contributes to cell survival in response to DNA damage through an activation of NHEJ DNA repair.
      Title: Nuclear TRADD prevents DNA damage-mediated death by facilitating non-homologous end-joining repair.
    9. potential biological significance of TRADD mediated inflammatory response in the development of uterine leiomyoma, is reported.
      Title: Identification of TRADD as a potential biomarker in human uterine leiomyoma through iTRAQ based proteomic profiling.
    10. we found that ORF3 protein downregulates TLR3-mediated NF-kappaB signaling via TRADD and RIP1. Our findings provide a new perspective on the cellular response in HEV infection and expand our understanding of the molecular mechanisms of Hepatitis E virus (HEV) pathogenesis in innate immunity.
      Title: The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11078

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables death domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in TRAIL-activated apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to tumor necrosis factor IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in extrinsic apoptotic signaling pathway via death domain receptors TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hair follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic side of plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of death-inducing signaling complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of tumor necrosis factor receptor superfamily complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tumor necrosis factor receptor superfamily complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor necrosis factor receptor type 1-associated DEATH domain protein
    Names
    TNFR1-associated death domain protein
    tumor necrosis factor receptor type 1 associated death domain protein
    tumor necrosis factor receptor-1-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323552.2 → NP_001310481.1  tumor necrosis factor receptor type 1-associated DEATH domain protein

      Status: REVIEWED

      Source sequence(s)
      AC074143, BT006934, CA426418, DA353575
      Consensus CDS
      CCDS10829.1
      UniProtKB/Swiss-Prot
      B2RDS3, B3KQZ9, Q15628, Q52NZ1
      Conserved Domains (2) summary
      pfam09034
      Location:51 → 160
      TRADD_N; TRADD, N-terminal domain
      cl14633
      Location:215 → 304
      DD; Death Domain Superfamily of protein-protein interaction domains

    2. NM_003789.4 → NP_003780.1  tumor necrosis factor receptor type 1-associated DEATH domain protein

      See identical proteins and their annotated locations for NP_003780.1

      Status: REVIEWED

      Source sequence(s)
      BC004491, CA426418, DA353575
      Consensus CDS
      CCDS10829.1
      UniProtKB/Swiss-Prot
      B2RDS3, B3KQZ9, Q15628, Q52NZ1
      Related
      ENSP00000341268.4, ENST00000345057.9
      Conserved Domains (2) summary
      pfam09034
      Location:51 → 160
      TRADD_N; TRADD, N-terminal domain
      cl14633
      Location:215 → 304
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67154185..67159909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      72948477..72954201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153425.1: Suppressed sequence

      Description
      NM_153425.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript variant.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15628.2 GenPept UniProtKB/Swiss-Prot:Q15628

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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