Adipor1 adiponectin receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adipor1provided by RGD
Official Full Name: adiponectin receptor 1provided by RGD
Primary source: RGD:1303151
See related: EnsemblRapid:ENSRNOG00000004143 AllianceGenome:RGD:1303151
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including adipokinetic hormone receptor activity; adiponectin binding activity; and identical protein binding activity. Involved in cytokine-mediated signaling pathway; negative regulation of cell growth; and positive regulation of signal transduction. Located in plasma membrane. Biomarker of end stage renal disease; hyperglycemia; hyperinsulinism; and obesity. Human ortholog(s) of this gene implicated in breast cancer; macular degeneration; and prostate adenocarcinoma. Orthologous to human ADIPOR1 (adiponectin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 570.8), Kidney (RPKM 454.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (48411438..48431251)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (45859461..45879248)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (51240470..51260233)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adiponectin receptor 1 could explain the sex differences in molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats.
Title: Adiponectin receptor 1 could explain the sex differences in molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats.
The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility.
Title: The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility.
Polyphenolic-rich Cissus quadrangularis extract ameliorates insulin resistance by activating AdipoR1 in peri-/post-menopausal rats.
Title: Polyphenolic-rich Cissus quadrangularis extract ameliorates insulin resistance by activating AdipoR1 in peri-/post-menopausal rats.
GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.
Title: GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.
High salt is an important suppressor of cardioprotective APN and AdipoR1 in cardiac myocytes.
Title: Regulation of the cardioprotective adiponectin and its receptor AdipoR1 by salt.
A High-fat maternal diet decreases adiponectin receptor 1 expression in the offspring.
Title: A high-fat maternal diet decreases adiponectin receptor-1 expression in offspring.
In a model of NAFLD, Adipor1 was primarily expressed in the cytoplasm of hepatocytes.
Title: Effects of a low-fat diet on the hepatic expression of adiponectin and its receptors in rats with NAFLD.
AdipoR1 and the adaptor protein APPL1 mediated the protective effects of gAcrp. In addition, the function of adiponectin and phosphorylation of AMPK were prominently diminished by inhibition of PI3K.
Title: AdipoR1/APPL1 potentiates the protective effects of globular adiponectin on angiotensin II-induced cardiac hypertrophy and fibrosis in neonatal rat atrial myocytes and fibroblasts.
Adipo R1 expression in kidney is increased in chronic renal failure
Title: Changes of adiponectin and its receptors in rats following chronic renal failure.
Adiponectin functions as a promoter of salivary secretion in rat submandibular glands via activation of Adiponectin receptors, AMPK, and paracellular permeability.
Title: Adiponectin increases secretion of rat submandibular gland via adiponectin receptors-mediated AMPK signaling.

Submit: New GeneRIF Correction See all GeneRIFs (34)

General gene information

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Markers

Adipor1 (e-PCR), detects polymorphism
- UniSTS:471066

RH16184 (e-PCR)
- UniSTS:46496

AA858656 (e-PCR)
- UniSTS:243416

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adipokinetic hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables adiponectin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adiponectin-activated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adiponectin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adiponectin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adiponectin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in leptin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adiponectin receptor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207587.2 → NP_997470.2 adiponectin receptor protein 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6ICB9, G3V6I6, Q3YAF8

Related

ENSRNOP00000005551.3, ENSRNOT00000005551.6

Conserved Domains (1) summary

pfam03006
Location:129 → 352

HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

48411438..48431251

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249852.5 → XP_006249914.1 adiponectin receptor protein 1 isoform X1

See identical proteins and their annotated locations for XP_006249914.1

UniProtKB/TrEMBL

A6ICB9, G3V6I6, Q3YAF8

Conserved Domains (1) summary

pfam03006
Location:129 → 352

HlyIII; Haemolysin-III related
XM_063272083.1 → XP_063128153.1 adiponectin receptor protein 1 isoform X1

UniProtKB/TrEMBL

A6ICB9, G3V6I6, Q3YAF8
XM_063272084.1 → XP_063128154.1 adiponectin receptor protein 1 isoform X1

UniProtKB/TrEMBL

A6ICB9, G3V6I6, Q3YAF8
XM_063272085.1 → XP_063128155.1 adiponectin receptor protein 1 isoform X1

UniProtKB/TrEMBL

A6ICB9, G3V6I6, Q3YAF8
XM_039090439.2 → XP_038946367.1 adiponectin receptor protein 1 isoform X1

UniProtKB/TrEMBL

A6ICB9, G3V6I6, Q3YAF8

Conserved Domains (1) summary

pfam03006
Location:129 → 352

HlyIII; Haemolysin-III related