Trim44 tripartite motif-containing 44 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trim44provided by RGD
Official Full Name: tripartite motif-containing 44provided by RGD
Primary source: RGD:1304877
See related: EnsemblRapid:ENSRNOG00000005191 AllianceGenome:RGD:1304877
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of protein K48-linked ubiquitination; positive regulation of defense response to virus by host; and positive regulation of signal transduction. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in aniridia. Orthologous to human TRIM44 (tripartite motif containing 44). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 315.2), Kidney (RPKM 171.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (109048643..109183821, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (88593619..88729085, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (91968781..92242138, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing of TRIM44 Inhibits Inflammation and Alleviates Traumatic Brain Injury in Rats by Downregulating TLR4-NF-kappaB Signaling.
Title: Silencing of TRIM44 Inhibits Inflammation and Alleviates Traumatic Brain Injury in Rats by Downregulating TLR4-NF-κB Signaling.

Submit: New GeneRIF Correction

General gene information

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Markers

AI579384 (e-PCR)
- UniSTS:249356

BE120249 (e-PCR)
- UniSTS:247277

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tripartite motif-containing protein 44

Names: DIPB protein; tripartite motif protein 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013203.2 → NP_001013221.1 tripartite motif-containing protein 44

See identical proteins and their annotated locations for NP_001013221.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q6QA27

UniProtKB/TrEMBL

A6HNN8, R9PXS7

Related

ENSRNOP00000007018.8, ENSRNOT00000007018.9

Conserved Domains (2) summary

cd19784
Location:177 → 215

Bbox2_TRIM44; B-box-type 2 zinc finger found in tripartite motif-containing protein 44 (TRIM44) and similar proteins

cd19841
Location:15 → 60

Bbox1_TRIM44; B-box-type 1 zinc finger found in tripartite motif-containing protein 44 (TRIM44) and similar proteins