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    Ankrd49 ankyrin repeat domain 49 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315434, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Ankrd49provided by RGD
    Official Full Name
    ankyrin repeat domain 49provided by RGD
    Primary source
    RGD:1311759
    See related
    EnsemblRapid:ENSRNOG00000009233 AllianceGenome:RGD:1311759
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311759
    Summary
    Predicted to be involved in positive regulation of transcription, DNA-templated. Predicted to be active in cytosol. Orthologous to human ANKRD49 (ankyrin repeat domain 49). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 84.7), Spleen (RPKM 80.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankrd49 in Genome Data Viewer
    Location:
    8q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (19908968..19913656, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (11627512..11632200, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (13299556..13304244, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094082 Neighboring gene similar to human chromosome 11 open reading frame 97 Neighboring gene MRE11 homolog, double strand break repair nuclease Neighboring gene G protein-coupled receptor 83 Neighboring gene uncharacterized LOC102549408

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. {gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice. Blau CA, et al. J Biol Chem, 2005 Nov 4. PMID 16131492
    2. Cloning and characterization of a potential transcriptional activator of human gamma-globin genes. Yang Y, et al. Blood Cells Mol Dis, 2001 Jan-Feb. PMID 11162141
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 49

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126283.1 → NP_001119755.1  ankyrin repeat domain-containing protein 49

      See identical proteins and their annotated locations for NP_001119755.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161982
      UniProtKB/TrEMBL
      A6JNA1, B1WC29
      Related
      ENSRNOP00000012583.4, ENSRNOT00000012583.6
      Conserved Domains (3) summary
      sd00045
      Location:78 → 105
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:78 → 170
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:160 → 216
      Ank_5; Ankyrin repeats (many copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      19908968..19913656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242525.4 → XP_006242587.1  ankyrin repeat domain-containing protein 49 isoform X1

      See identical proteins and their annotated locations for XP_006242587.1

      UniProtKB/TrEMBL
      A6JNA1, B1WC29
      Conserved Domains (3) summary
      sd00045
      Location:78 → 105
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:78 → 170
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:160 → 216
      Ank_5; Ankyrin repeats (many copies)

    2. XM_039081350.2 → XP_038937278.1  ankyrin repeat domain-containing protein 49 isoform X1

      UniProtKB/TrEMBL
      A6JNA1, B1WC29
      Conserved Domains (3) summary
      sd00045
      Location:78 → 105
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:78 → 170
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:160 → 216
      Ank_5; Ankyrin repeats (many copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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