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    PLPPR2 phospholipid phosphatase related 2 [ Homo sapiens (human) ]

    Gene ID: 64748, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PLPPR2provided by HGNC
    Official Full Name
    phospholipid phosphatase related 2provided by HGNC
    Primary source
    HGNC:HGNC:29566
    See related
    Ensembl:ENSG00000105520 MIM:619591; AllianceGenome:HGNC:29566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRG4; LPPR2
    Summary
    Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in brain (RPKM 26.0), prostate (RPKM 12.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PLPPR2 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11355432..11365698)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11482410..11492670)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11466108..11476374)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 205 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11456465-11457295 Neighboring gene coiled-coil domain containing 159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11461146-11461646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11467020-11467961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14012 Neighboring gene SWIM-type zinc finger 7 associated protein 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11492093-11492630 Neighboring gene erythropoietin receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14015 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10110

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. Savaskan NE, et al. Eur J Neurosci, 2004 Jan. PMID 14750979
    2. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Maruyama K, et al. Gene, 1994 Jan 28. PMID 8125298
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
    5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13055, DKFZp761E1121

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid phosphatase-related protein type 2
    Names
    inactive phospholipid phosphatase PLPPR2
    lipid phosphate phosphatase-related protein type 2
    plasticity related gene 4
    plasticity-related gene 4 protein
    NP_001164106.1
    NP_001380821.1
    NP_001380822.1
    NP_001380823.1
    NP_001380824.1
    NP_001380825.1
    NP_073574.2
    XP_016882637.1
    XP_054177753.1
    XP_054177754.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170635.2 → NP_001164106.1  phospholipid phosphatase-related protein type 2 isoform 2

      See identical proteins and their annotated locations for NP_001164106.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      AK094869, BC009378, DB169285
      Consensus CDS
      CCDS59352.1
      UniProtKB/Swiss-Prot
      Q96GM1
      Related
      ENSP00000466898.1, ENST00000591608.2
      Conserved Domains (1) summary
      cd03384
      Location:100 → 256
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    2. NM_001393892.1 → NP_001380821.1  phospholipid phosphatase-related protein type 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC024575
      Consensus CDS
      CCDS92519.1
      UniProtKB/TrEMBL
      A0A8I5KWF3
      Related
      ENSP00000510269.1, ENST00000688289.1
      Conserved Domains (1) summary
      cd03384
      Location:125 → 281
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    3. NM_001393893.1 → NP_001380822.1  phospholipid phosphatase-related protein type 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC024575
      Consensus CDS
      CCDS92519.1
      UniProtKB/TrEMBL
      A0A8I5KWF3
      Conserved Domains (1) summary
      cd03384
      Location:125 → 281
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    4. NM_001393894.1 → NP_001380823.1  phospholipid phosphatase-related protein type 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC024575
      Consensus CDS
      CCDS12258.1
      UniProtKB/Swiss-Prot
      Q5CZ76, Q8N1U4, Q96GM1, Q9H929
      Conserved Domains (1) summary
      cd03384
      Location:125 → 281
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    5. NM_001393895.1 → NP_001380824.1  phospholipid phosphatase-related protein type 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC024575
      Conserved Domains (1) summary
      cd03384
      Location:100 → 256
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    6. NM_001393896.1 → NP_001380825.1  phospholipid phosphatase-related protein type 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC024575

    7. NM_022737.3 → NP_073574.2  phospholipid phosphatase-related protein type 2 isoform 1

      See identical proteins and their annotated locations for NP_073574.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AK023117, AY304516, BC009378
      Consensus CDS
      CCDS12258.1
      UniProtKB/Swiss-Prot
      Q5CZ76, Q8N1U4, Q96GM1, Q9H929
      Related
      ENSP00000251473.4, ENST00000251473.9
      Conserved Domains (1) summary
      cd03384
      Location:125 → 281
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      11355432..11365698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027148.2 → XP_016882637.1  phospholipid phosphatase-related protein type 2 isoform X1

      UniProtKB/Swiss-Prot
      Q96GM1
      Conserved Domains (1) summary
      cd03384
      Location:100 → 256
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      11482410..11492670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321778.1 → XP_054177753.1  phospholipid phosphatase-related protein type 2 isoform X1

    2. XM_054321779.1 → XP_054177754.1  phospholipid phosphatase-related protein type 2 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96GM1.1 GenPept UniProtKB/Swiss-Prot:Q96GM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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