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    LINC00607 long intergenic non-protein coding RNA 607 [ Homo sapiens (human) ]

    Gene ID: 646324, updated on 17-Sep-2024

    Summary

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    Official Symbol
    LINC00607provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 607provided by HGNC
    Primary source
    HGNC:HGNC:43944
    See related
    Ensembl:ENSG00000235770 AllianceGenome:HGNC:43944
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See LINC00607 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (215611563..215843536, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (216097003..216328916, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216476286..216708259, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12300 Neighboring gene fibronectin 1 Neighboring gene uncharacterized LOC102724849 Neighboring gene Sharpr-MPRA regulatory region 5619 Neighboring gene FN1 divergent transcript Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:216392847-216394046 Neighboring gene uncharacterized LOC102724861 Neighboring gene Sharpr-MPRA regulatory region 4559 Neighboring gene NANOG hESC enhancer GRCh37_chr2:216491401-216491902 Neighboring gene uncharacterized LOC124906139 Neighboring gene long intergenic non-protein coding RNA 1614 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:216627282-216628481 Neighboring gene Sharpr-MPRA regulatory region 2478 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17075 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17076 Neighboring gene uncharacterized LOC105373870 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:216786644-216787283 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:216787284-216787924 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:216792334-216792860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17079 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:216877329-216878096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17082 Neighboring gene melanoregulin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17083 Neighboring gene peroxisomal trans-2-enoyl-CoA reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MYC-activated LINC00607 promotes hepatocellular carcinoma progression by regulating the miR-584-3p/ROCK1 axis. Dong S, et al. J Gene Med, 2023 Apr. PMID 36740760
    2. The endothelial-enriched lncRNA LINC00607 mediates angiogenic function. Boos F, et al. Basic Res Cardiol, 2023 Jan 26. PMID 36700983, Free PMC Article
    3. Vascular Regulation by Super Enhancer-Derived LINC00607. Sriram K, et al. Front Cardiovasc Med, 2022. PMID 35837599, Free PMC Article
    4. Genome-wide association study of smoking behaviours among Bangladeshi adults. Argos M, et al. J Med Genet, 2014 May. PMID 24665060, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MYC-activated LINC00607 promotes hepatocellular carcinoma progression by regulating the miR-584-3p/ROCK1 axis.
      Title: MYC-activated LINC00607 promotes hepatocellular carcinoma progression by regulating the miR-584-3p/ROCK1 axis.
    2. The endothelial-enriched lncRNA LINC00607 mediates angiogenic function.
      Title: The endothelial-enriched lncRNA LINC00607 mediates angiogenic function.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of smoking behaviours among Bangladeshi adults.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Clone Names

    • AC122136.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_037195.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC012668, AK124897
      Related
      ENST00000445174.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      215611563..215843536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      216097003..216328916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials