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    MOCS3 molybdenum cofactor synthesis 3 [ Homo sapiens (human) ]

    Gene ID: 27304, updated on 28-Oct-2024

    Summary

    Official Symbol
    MOCS3provided by HGNC
    Official Full Name
    molybdenum cofactor synthesis 3provided by HGNC
    Primary source
    HGNC:HGNC:15765
    See related
    Ensembl:ENSG00000124217 MIM:609277; AllianceGenome:HGNC:15765
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBA4
    Summary
    Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012]
    Orthologs
    NEW
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    Genomic context

    See MOCS3 in Genome Data Viewer
    Location:
    20q13.13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (50958818..50963929)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (52729421..52734532)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (49575355..49580466)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene activity dependent neuroprotector homeobox Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49541986-49542486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49542487-49542987 Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13033 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:49546803-49547593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18107 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:49548232-49548419 Neighboring gene ADNP antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49575528-49576138 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 1, catalytic Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49606180-49607142 Neighboring gene Sharpr-MPRA regulatory region 8647 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49620535-49621036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49637285-49637848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13038 Neighboring gene potassium voltage-gated channel modifier subfamily G member 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:49651184-49652168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49674148-49674648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49693483-49693982 Neighboring gene NANOG hESC enhancer GRCh37_chr20:49703630-49704209 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:49709053-49710038 Neighboring gene uncharacterized LOC105372661 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:49735490-49736325 Neighboring gene uncharacterized LOC105372662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49737507-49738012

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC9252, dJ914P20.3

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables URM1 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables URM1 activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molybdopterin-synthase adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molybdopterin-synthase sulfurtransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molybdopterin-synthase sulfurtransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables nucleotidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleotidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sulfurtransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sulfurtransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables thiosulfate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    adenylyltransferase and sulfurtransferase MOCS3
    Names
    MPT synthase sulfurylase
    UBA4, ubiquitin-activating enzyme E1 homolog
    molybdenum cofactor synthesis protein 3
    molybdopterin synthase sulfurylase
    ubiquitin-like modifier activating enzyme 4
    NP_055299.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014484.5NP_055299.1  adenylyltransferase and sulfurtransferase MOCS3

      See identical proteins and their annotated locations for NP_055299.1

      Status: REVIEWED

      Source sequence(s)
      AF102544, AI942426, AL034553, BC015939, BQ188547, BY995583, DB452633, HY215239
      Consensus CDS
      CCDS13435.1
      UniProtKB/Swiss-Prot
      O95396
      Related
      ENSP00000244051.1, ENST00000244051.3
      Conserved Domains (2) summary
      cd00757
      Location:62285
      ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
      cd01526
      Location:327460
      RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      50958818..50963929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      52729421..52734532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)