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    DHRS2 dehydrogenase/reductase 2 [ Homo sapiens (human) ]

    Gene ID: 10202, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DHRS2provided by HGNC
    Official Full Name
    dehydrogenase/reductase 2provided by HGNC
    Primary source
    HGNC:HGNC:18349
    See related
    Ensembl:ENSG00000100867 MIM:615194; AllianceGenome:HGNC:18349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HEP27; SDR25C1
    Summary
    This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
    Expression
    Biased expression in urinary bladder (RPKM 75.6), salivary gland (RPKM 7.2) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DHRS2 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23630115..23645639)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17830743..17846267)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24099324..24114848)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene thiamine triphosphatase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24031286-24031786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24031787-24032287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8175 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5611 Neighboring gene AP1G2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24046010-24046770 Neighboring gene adaptor related protein complex 1 subunit gamma 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24054355-24054854 Neighboring gene junctophilin 4 Neighboring gene Sharpr-MPRA regulatory region 10629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8178 Neighboring gene uncharacterized LOC105370407 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:24139233-24140432 Neighboring gene uncharacterized LOC105370408 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:24163587-24164103

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family. Gabrielli F, et al. Eur J Biochem, 1995 Sep 1. PMID 7556196
    2. Regulatory mechanism of DHRS2-modified human umbilical cord mesenchymal stem cells-derived exosomes in prostate cancer cell proliferation and apoptosis. Wu X, et al. Tissue Cell, 2023 Jun. PMID 37060745
    3. Potential tumor suppressor role for the c-Myb oncogene in luminal breast cancer. Thorner AR, et al. PLoS One, 2010 Oct 7. PMID 20949095, Free PMC Article
    4. DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism. Li Z, et al. Cell Death Dis, 2022 Oct 3. PMID 36192391, Free PMC Article
    5. Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors. Nettersheim D, et al. J Cell Mol Med, 2019 Jan. PMID 30460772, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulatory mechanism of DHRS2-modified human umbilical cord mesenchymal stem cells-derived exosomes in prostate cancer cell proliferation and apoptosis.
      Title: Regulatory mechanism of DHRS2-modified human umbilical cord mesenchymal stem cells-derived exosomes in prostate cancer cell proliferation and apoptosis.
    2. Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma.
      Title: Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma.
    3. DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKalpha to disrupt choline metabolism.
      Title: DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism.
    4. LEF1 Induces DHRS2 Gene Expression in Human Acute Leukemia Jurkat T-Cells
      Title: LEF1 Induces DHRS2 Gene Expression in Human Acute Leukemia Jurkat T-Cells.
    5. Decreased DHRS2 expression is associated with HDACi resistance and poor prognosis in ovarian cancer.
      Title: Decreased DHRS2 expression is associated with HDACi resistance and poor prognosis in ovarian cancer.
    6. DHRS2 is dispensable for up-regulation of romidepsin effectors.
      Title: Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors.
    7. Results show that DHRS2 is highly expressed in oxaliplatin-resistant colorectal cancer (CRC) cell line. Furthermore, DHRS2 regulates ERCC1 to promote oxaliplatin resistance through a p53dependent pathway, and mediates EMT by suppressing Ecadherin expression.
      Title: Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.
    8. Our report suggests that activating DHRS2 to reprogram lipid homeostasis may be a target for the development of targeted therapies against NPC.
      Title: DHRS2 mediates cell growth inhibition induced by Trichothecin in nasopharyngeal carcinoma.
    9. Among these targets, dehydrogenase/reductase member 2 DHRS2 and MYO1B were directly regulated by miR1453p in esophageal squamous cell carcinoma (ESCC) cells by dual luciferase reporter assays. Aberrantly expressed DHRS2 and MYOIB were detected in ESCC clinical specimens, and their overexpression enhanced cancer cell aggressiveness.
      Title: Molecular pathogenesis of esophageal squamous cell carcinoma: Identification of the antitumor effects of miR‑145‑3p on gene regulation.
    10. Low DHRS2 expression promotes esophageal squamous cell carcinoma.
      Title: DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20338

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonyl reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in C21-steroid hormone metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in myeloid dendritic cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to toxic substance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 2, mitochondrial
    Names
    dehydrogenase/reductase (SDR family) member 2
    dehydrogenase/reductase member 2
    dicarbonyl reductase HEP27
    protein D
    short chain dehydrogenase/reductase family 25C member 1
    short-chain alcohol dehydrogenase family member

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318835.1 → NP_001305764.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 1. This results in a protein that is shorter at the C-terminus, compared to isoform 1. The promoter used by this transcript is a hepatocyte specific promoter.
      Source sequence(s)
      AK309975, AL135999
      UniProtKB/TrEMBL
      Q59F08
      Related
      ENST00000553896.5
      Conserved Domains (1) summary
      cl21454
      Location:27 → 140
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_005794.4 → NP_005785.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_005785.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). The promoter used by this transcript is a hepatocyte-specific promoter.
      Source sequence(s)
      AK222857, U31875
      Consensus CDS
      CCDS9604.1
      UniProtKB/Swiss-Prot
      D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2
      UniProtKB/TrEMBL
      C9JZP6
      Related
      ENSP00000250383.7, ENST00000250383.11
      Conserved Domains (1) summary
      cl21454
      Location:27 → 275
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_182908.5 → NP_878912.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_878912.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). The promoter and 5' terminal exon sequence is from an endogenous retroviral LTR. (PMID: 11944995) This promoter is specifically active in human monocyte-derived dendritic cells.
      Source sequence(s)
      AL135999, BC002786
      Consensus CDS
      CCDS41927.1
      UniProtKB/Swiss-Prot
      Q13268
      Related
      ENSP00000344674.7, ENST00000344777.11
      Conserved Domains (1) summary
      cl25409
      Location:27 → 226
      SDR; Short-chain dehydrogenases/reductases (SDR)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      23630115..23645639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005267249.1 → XP_005267306.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005267306.1

      UniProtKB/Swiss-Prot
      D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2
      UniProtKB/TrEMBL
      C9JZP6
      Related
      ENSP00000401213.2, ENST00000432832.6
      Conserved Domains (1) summary
      cl21454
      Location:27 → 275
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_011536339.3 → XP_011534641.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011534641.1

      UniProtKB/TrEMBL
      H0YJP4
      Related
      ENSP00000451895.1, ENST00000557535.5
      Conserved Domains (1) summary
      cl21454
      Location:1 → 199
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_006720001.4 → XP_006720064.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006720064.1

      UniProtKB/Swiss-Prot
      D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2
      UniProtKB/TrEMBL
      C9JZP6
      Conserved Domains (1) summary
      cl21454
      Location:27 → 275
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_011536338.2 → XP_011534640.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011534640.1

      UniProtKB/TrEMBL
      H0YJP4
      Conserved Domains (1) summary
      cl21454
      Location:1 → 199
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    5. XM_047430874.1 → XP_047286830.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2

    RNA

    1. XR_007063975.1 RNA Sequence

    2. XR_007063976.1 RNA Sequence

    3. XR_007063974.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      17830743..17846267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375248.1 → XP_054231223.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2

    2. XM_054375252.1 → XP_054231227.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2

    3. XM_054375249.1 → XP_054231224.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2

    4. XM_054375251.1 → XP_054231226.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X2

    5. XM_054375250.1 → XP_054231225.1  dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      D3DS54, Q13268, Q53GS4, Q7Z789, Q9H2R2

    RNA

    1. XR_008488811.1 RNA Sequence

    2. XR_008488812.1 RNA Sequence

    3. XR_008488810.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13268.4 GenPept UniProtKB/Swiss-Prot:Q13268

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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