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    SPDYE2 speedy/RINGO cell cycle regulator family member E2 [ Homo sapiens (human) ]

    Gene ID: 441273, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SPDYE2provided by HGNC
    Official Full Name
    speedy/RINGO cell cycle regulator family member E2provided by HGNC
    Primary source
    HGNC:HGNC:33841
    See related
    Ensembl:ENSG00000205238 MIM:617624; AllianceGenome:HGNC:33841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPDYB2L1; SPDYB2-L1
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 4.7), spleen (RPKM 2.6) and 24 other tissues See more
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    Genomic context

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    See SPDYE2 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102551226..102565227)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103865641..103881058)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102191673..102203985)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RAS p21 protein activator 4B Neighboring gene uncharacterized LOC124901715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102151767-102152268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102152269-102152768 Neighboring gene Sharpr-MPRA regulatory region 3260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102156842-102157466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102165421-102165922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102165923-102166422 Neighboring gene POLR2J3-UPK3BL2 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102179485-102180312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102184221-102184721 Neighboring gene uroplakin 3B like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102212169-102212830 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:102213197-102213370 Neighboring gene uncharacterized LOC124901712 Neighboring gene RNA polymerase II subunit J3 Neighboring gene RAS p21 protein activator 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Evolution of the Cdk-activator Speedy/RINGO in vertebrates. Chauhan S, et al. Cell Mol Life Sci, 2012 Nov. PMID 22763696, Free PMC Article
    2. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article
    3. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
    4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Clone Names

    • MGC119295

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    speedy protein E2
    Names
    Speedy B2-like 1
    putative Speedy protein E2
    speedy homolog E2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031618.3 → NP_001026789.2  speedy protein E2

      See identical proteins and their annotated locations for NP_001026789.2

      Status: VALIDATED

      Source sequence(s)
      AC093668, AK302217, BF809327, DR731150
      Consensus CDS
      CCDS34716.2
      UniProtKB/Swiss-Prot
      B4DY11, Q495Y8
      UniProtKB/TrEMBL
      I6XC90
      Related
      ENSP00000421686.1, ENST00000507918.6
      Conserved Domains (1) summary
      pfam11357
      Location:194 → 398
      Spy1; Cell cycle regulatory protein

    2. NM_001396242.1 → NP_001383171.1  speedy protein E2

      Status: VALIDATED

      Source sequence(s)
      AC093668
      Consensus CDS
      CCDS34716.2
      UniProtKB/Swiss-Prot
      B4DY11, Q495Y8
      UniProtKB/TrEMBL
      I6XC90
      Related
      ENSP00000509749.1, ENST00000691607.2
      Conserved Domains (1) summary
      pfam11357
      Location:194 → 398
      Spy1; Cell cycle regulatory protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      102551226..102565227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516237.4 → XP_011514539.1  speedy protein E2 isoform X1

      Conserved Domains (1) summary
      pfam11357
      Location:194 → 303
      Spy1; Cell cycle regulatory protein

    2. XM_047420405.1 → XP_047276361.1  speedy protein E2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      103865641..103881058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358263.1 → XP_054214238.1  speedy protein E2 isoform X5

    2. XM_054358262.1 → XP_054214237.1  speedy protein E2 isoform X4

    3. XM_054358261.1 → XP_054214236.1  speedy protein E2 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q495Y8.2 GenPept UniProtKB/Swiss-Prot:Q495Y8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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