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    C16orf95 chromosome 16 open reading frame 95 [ Homo sapiens (human) ]

    Gene ID: 100506581, updated on 17-Sep-2024

    Summary

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    Official Symbol
    C16orf95provided by HGNC
    Official Full Name
    chromosome 16 open reading frame 95provided by HGNC
    Primary source
    HGNC:HGNC:40033
    See related
    Ensembl:ENSG00000260456 AllianceGenome:HGNC:40033
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in testis (RPKM 33.1) and bone marrow (RPKM 1.2) See more
    Orthologs
    mouse all
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    Genomic context

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    See C16orf95 in Genome Data Viewer
    Location:
    16q24.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (87302814..87317392, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (93373698..93388274, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87336420..87350998, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928682 Neighboring gene ribosomal protein L39 pseudogene 30 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87312649-87313154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87329362-87330350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87330351-87331337 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87339626-87340209 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87348819-87349319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11320 Neighboring gene C16orf95 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87364853-87365354 Neighboring gene F-box protein 31 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87379751-87380306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87380307-87380861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87386425-87386966 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:87399801-87400302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87403399-87404245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7833 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:87417185-87417838 Neighboring gene uncharacterized LOC124903747 Neighboring gene tRNA-Met (anticodon CAT) 6-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identifying new associated pleiotropic SNPs with lipids by simultaneous test of multiple longitudinal traits: An Iranian family-based study. Hosseinzadeh N, et al. Gene, 2019 Apr 15. PMID 30658068
    2. Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method. Oshikawa M, et al. DNA Res, 2008 Jun 30. PMID 18487259, Free PMC Article
    3. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
    4. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901, Free PMC Article
    5. From ORFeome to biology: a functional genomics pipeline. Wiemann S, et al. Genome Res, 2004 Oct. PMID 15489336, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: FBXO31

    Homology

    Clone Names

    • FLJ22477, DKFZp434J1815

    General protein information

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    Preferred Names
    uncharacterized protein C16orf95

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195124.3 → NP_001182053.1  uncharacterized protein C16orf95 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC010531
      Consensus CDS
      CCDS58491.1
      UniProtKB/TrEMBL
      H3BNZ7
      Related
      ENSP00000455079.2, ENST00000567970.2
      Conserved Domains (1) summary
      pfam15132
      Location:76 → 239
      DUF4568; Domain of unknown function (DUF4568)

    2. NM_001195125.3 → NP_001182054.1  uncharacterized protein C16orf95 isoform 2

      See identical proteins and their annotated locations for NP_001182054.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC010531, BC015536, BU839368
      Consensus CDS
      CCDS54049.1
      UniProtKB/Swiss-Prot
      Q9H693
      Related
      ENSP00000253461.4, ENST00000253461.8
      Conserved Domains (1) summary
      pfam15132
      Location:76 → 110
      DUF4568; Domain of unknown function (DUF4568)

    3. NM_001256917.2 → NP_001243846.1  uncharacterized protein C16orf95 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon and an alternate start codon, and lacks two exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) shares similarity in the central region but has distinct N- and C-termini and is overall shorter, compared to isoform 1.
      Source sequence(s)
      AB371437, AC010531, BC015536, BI460222, BU839368, DA871621
      Consensus CDS
      CCDS73921.1
      UniProtKB/TrEMBL
      A0A087X224
      Related
      ENSP00000484646.1, ENST00000618367.4
      Conserved Domains (1) summary
      pfam15132
      Location:54 → 95
      DUF4568; Domain of unknown function (DUF4568)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      87302814..87317392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      93373698..93388274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H693.1 GenPept UniProtKB/Swiss-Prot:Q9H693

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