RAB24 RAB24, member RAS oncogene family [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB24provided by HGNC
Official Full Name: RAB24, member RAS oncogene familyprovided by HGNC
Primary source: HGNC:HGNC:9765
See related: Ensembl:ENSG00000169228 MIM:612415; AllianceGenome:HGNC:9765
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009]
Expression: Ubiquitous expression in spleen (RPKM 20.5), appendix (RPKM 14.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q35.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (177301198..177303719, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (177844433..177846953, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (176728199..176730720, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity.
Title: Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity.
Our work provides new insights into the molecular function of Rab24 in the last steps of the endosomal degradative pathway.
Title: Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation.
Rab24 modulates several mitotic events, including chromosome segregation and cytokinesis, perhaps through the interaction with microtubules
Title: Rab24 is required for normal cell division.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HTP more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: ras-related protein Rab-24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031677.4 → NP_001026847.1 ras-related protein Rab-24

See identical proteins and their annotated locations for NP_001026847.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AF087904, AI868941, AV698158, BC021263, DA898352

Consensus CDS

CCDS34300.1

UniProtKB/Swiss-Prot

A0A024R7N9, Q7Z4Z7, Q969Q5

UniProtKB/TrEMBL

F8W8H5

Related

ENSP00000304376.6, ENST00000303251.11

Conserved Domains (1) summary

cd04118
Location:8 → 201

Rab24; Rab GTPase family 24 (Rab24)
NM_130781.4 → NP_570137.2 ras-related protein Rab-24

See identical proteins and their annotated locations for NP_570137.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AF087904, AI868941, AV698158, BC015534, DA898352

Consensus CDS

CCDS34300.1

UniProtKB/Swiss-Prot

A0A024R7N9, Q7Z4Z7, Q969Q5

UniProtKB/TrEMBL

F8W8H5

Related

ENSP00000377235.2, ENST00000393611.6

Conserved Domains (1) summary

cd04118
Location:8 → 201

Rab24; Rab GTPase family 24 (Rab24)

RNA

NR_109789.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks a segment in the 5' region, and includes an additional internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF087904, AF258583, AI868941, AK308155, AV698158, DA898352
NR_109790.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) includes an additional internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF087904, AF258583, AI868941, AV698158, DA058886

Related

ENST00000478234.5