U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CCDC149 coiled-coil domain containing 149 [ Homo sapiens (human) ]

    Gene ID: 91050, updated on 17-Sep-2024

    Summary

    Official Symbol
    CCDC149provided by HGNC
    Official Full Name
    coiled-coil domain containing 149provided by HGNC
    Primary source
    HGNC:HGNC:25405
    See related
    Ensembl:ENSG00000181982 AllianceGenome:HGNC:25405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in brain (RPKM 7.3), ovary (RPKM 5.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CCDC149 in Genome Data Viewer
    Location:
    4p15.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (24803514..24980204, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (24785445..24962121, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (24805136..24981826, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 65 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:24801347-24801847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:24810365-24810945 Neighboring gene superoxide dismutase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:24858054-24858554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:24858555-24859055 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:24864823-24866022 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:24870157-24871356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:24918461-24919030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:24919031-24919599 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:24966942-24968141 Neighboring gene uncharacterized LOC102723675 Neighboring gene leucine rich repeat LGI family member 2 Neighboring gene uncharacterized LOC124900684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:25086876-25087376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:25087377-25087877 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:25089726-25090269 Neighboring gene uncharacterized LOC105374534

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13410, DKFZp761B107

    General protein information

    Preferred Names
    coiled-coil domain-containing protein 149

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130726.5NP_001124198.2  coiled-coil domain-containing protein 149 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC006390, AC116422
      Consensus CDS
      CCDS47036.2
      UniProtKB/TrEMBL
      A0A8V8PSJ6
      Related
      ENSP00000425715.2, ENST00000504487.5
      Conserved Domains (2) summary
      TIGR01612
      Location:146451
      235kDa-fam; reticulocyte binding/rhoptry protein
      COG1196
      Location:21263
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    2. NM_001330644.2NP_001317573.1  coiled-coil domain-containing protein 149 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC006390, AC116422, AK296454, AL545064, BQ671265, CB243678, DB500831
      UniProtKB/Swiss-Prot
      A6NJE7, B4DK90, B4DZG3, G5EA04, Q6NW41, Q6ZUS6, Q8N3K8
    3. NM_001395273.1NP_001382202.1  coiled-coil domain-containing protein 149 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC006390, AC116422, AK296454, AL545064, CB243678, DB500831
      Consensus CDS
      CCDS82914.2
      UniProtKB/TrEMBL
      A0A0U1RQD2
      Related
      ENSP00000488929.2, ENST00000635206.3
      Conserved Domains (1) summary
      COG1196
      Location:21276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    4. NM_173463.6NP_775734.2  coiled-coil domain-containing protein 149 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC006390, AK302905, CB243678, DB244172
      Consensus CDS
      CCDS33967.2
      UniProtKB/Swiss-Prot
      Q6ZUS6
      Related
      ENSP00000374260.4, ENST00000389609.8
      Conserved Domains (2) summary
      pfam09789
      Location:26338
      DUF2353; Uncharacterized coiled-coil protein (DUF2353)
      cl00459
      Location:91211
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      24803514..24980204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513908.3XP_011512210.1  coiled-coil domain-containing protein 149 isoform X3

      See identical proteins and their annotated locations for XP_011512210.1

      Conserved Domains (2) summary
      pfam09789
      Location:1283
      DUF2353; Uncharacterized coiled-coil protein (DUF2353)
      cl00459
      Location:36156
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    2. XM_011513907.4XP_011512209.1  coiled-coil domain-containing protein 149 isoform X3

      See identical proteins and their annotated locations for XP_011512209.1

      Conserved Domains (2) summary
      pfam09789
      Location:1283
      DUF2353; Uncharacterized coiled-coil protein (DUF2353)
      cl00459
      Location:36156
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    3. XM_017008827.3XP_016864316.1  coiled-coil domain-containing protein 149 isoform X2

      UniProtKB/Swiss-Prot
      Q6ZUS6
      Conserved Domains (2) summary
      pfam09789
      Location:26338
      DUF2353; Uncharacterized coiled-coil protein (DUF2353)
      cl00459
      Location:91211
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    4. XM_011513906.4XP_011512208.1  coiled-coil domain-containing protein 149 isoform X1

      Conserved Domains (2) summary
      pfam09789
      Location:26338
      DUF2353; Uncharacterized coiled-coil protein (DUF2353)
      cl00459
      Location:91211
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      24785445..24962121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351222.1XP_054207197.1  coiled-coil domain-containing protein 149 isoform X3

    2. XM_054351221.1XP_054207196.1  coiled-coil domain-containing protein 149 isoform X3

    3. XM_054351220.1XP_054207195.1  coiled-coil domain-containing protein 149 isoform X2

    4. XM_054351219.1XP_054207194.1  coiled-coil domain-containing protein 149 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001330643.2: Suppressed sequence

      Description
      NM_001330643.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.