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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_012820.2Â RefSeqGene
- Range
-
104141..248538
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_000037.4 → NP_000028.3  ankyrin-1 isoform 3
See identical proteins and their annotated locations for NP_000028.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) has an alternate segment in the 3' coding region, which includes a stop codon, compared to variant 1. The resulting isoform (3) has a distinct and one aa shorter C-terminus, compared to isoform 1.
- Source sequence(s)
-
AB209418, AC113133, M28880, N63745, X16609
- Consensus CDS
-
CCDS6121.1
- UniProtKB/Swiss-Prot
-
P16157
- Related
- ENSP00000289734.8, ENST00000289734.13
- Conserved Domains (10) summary
-
- smart00218
Location:911 → 1015
- ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
- smart00248
Location:601 → 630
- ANK; ankyrin repeats
- COG0666
Location:341 → 554
- ANKYR; Ankyrin repeat [Signal transduction mechanisms]
- cd00204
Location:365 → 490
- ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
- cd08805
Location:1401 → 1484
- Death_ank1; Death domain of Ankyrin-1
- pfam00023
Location:337 → 367
- Ank; Ankyrin repeat
- pfam12796
Location:639 → 730
- Ank_2; Ankyrin repeats (3 copies)
- pfam13637
Location:14 → 65
- Ank_4; Ankyrin repeats (many copies)
- pfam13857
Location:720 → 774
- Ank_5; Ankyrin repeats (many copies)
- sd00045
Location:403 → 434
- ANK; ANK repeat [structural motif]
-
NM_001142445.2 → NP_001135917.1  ankyrin-1 isoform 10
Status: REVIEWED
- Description
- Transcript Variant: This variant (10) lacks multiple 5' exons, but has an alternate 5' exon which includes an AUG start codon, compared to variant 1. The resulting isoform (10) has a much shorter and distinct N-terminus, compared to isoform 1.
- Source sequence(s)
-
AC113133, BC014467, N63745
- Consensus CDS
-
CCDS55227.1
- UniProtKB/Swiss-Prot
-
P16157
- Related
- ENSP00000430368.1, ENST00000522543.6
-
NM_001142446.2 → NP_001135918.1  ankyrin-1 isoform 9
Status: REVIEWED
- Description
- Transcript Variant: This variant (9) has an alternate upstream 5' exon, which includes an AUG start codon, and has an additional exon in the middle region, but lacks a segment in the 3' coding region, compared to variant 1. The reading frame is not affected and the resulting isoform (9) is the longest, which has a distinct N-terminus and an internal additional segment as well as lacks a segment in the C-terminal region, compared to isoform 1.
- Source sequence(s)
-
AB209418, AC027702, AC113133, N63745, X16609
- Consensus CDS
-
CCDS47849.1
- UniProtKB/Swiss-Prot
-
P16157
- Related
- ENSP00000265709.8, ENST00000265709.14
- Conserved Domains (10) summary
-
- smart00218
Location:952 → 1056
- ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
- smart00248
Location:634 → 663
- ANK; ankyrin repeats
- COG0666
Location:374 → 587
- ANKYR; Ankyrin repeat [Signal transduction mechanisms]
- cd00204
Location:398 → 523
- ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
- cd08805
Location:1442 → 1525
- Death_ank1; Death domain of Ankyrin-1
- pfam00023
Location:370 → 400
- Ank; Ankyrin repeat
- pfam12796
Location:672 → 763
- Ank_2; Ankyrin repeats (3 copies)
- pfam13637
Location:47 → 98
- Ank_4; Ankyrin repeats (many copies)
- pfam13857
Location:753 → 807
- Ank_5; Ankyrin repeats (many copies)
- sd00045
Location:436 → 467
- ANK; ANK repeat [structural motif]
-
NM_020475.3 → NP_065208.2  ankyrin-1 isoform 4
See identical proteins and their annotated locations for NP_065208.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) lacks an in-frame segment in the 3' coding region, compared to variant 1. The resulting isoform (4) is therefore shorter than isoform 1.
- Source sequence(s)
-
AA404587, AB209418, AC113133, M28880, N63745, X16609
- UniProtKB/Swiss-Prot
-
P16157
- Conserved Domains (10) summary
-
- smart00218
Location:911 → 1015
- ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
- smart00248
Location:601 → 630
- ANK; ankyrin repeats
- COG0666
Location:341 → 554
- ANKYR; Ankyrin repeat [Signal transduction mechanisms]
- cd00204
Location:365 → 490
- ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
- cd08805
Location:1401 → 1484
- Death_ank1; Death domain of Ankyrin-1
- pfam00023
Location:337 → 367
- Ank; Ankyrin repeat
- pfam12796
Location:639 → 730
- Ank_2; Ankyrin repeats (3 copies)
- pfam13637
Location:14 → 65
- Ank_4; Ankyrin repeats (many copies)
- pfam13857
Location:720 → 774
- Ank_5; Ankyrin repeats (many copies)
- sd00045
Location:403 → 434
- ANK; ANK repeat [structural motif]
-
NM_020476.3 → NP_065209.2  ankyrin-1 isoform 1
See identical proteins and their annotated locations for NP_065209.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes isoform 1, also referred to as isoform 2.1.
- Source sequence(s)
-
AB209418, AC113133, M28880, N63745, X16609
- Consensus CDS
-
CCDS6119.1
- UniProtKB/Swiss-Prot
- A0PJN8, A6NJ23, E5RFL7, O43400, P16157, Q13768, Q53ER1, Q59FP2, Q8N604, Q99407
- Related
- ENSP00000339620.4, ENST00000347528.8
- Conserved Domains (10) summary
-
- smart00218
Location:911 → 1015
- ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
- smart00248
Location:601 → 630
- ANK; ankyrin repeats
- COG0666
Location:341 → 554
- ANKYR; Ankyrin repeat [Signal transduction mechanisms]
- cd00204
Location:365 → 490
- ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
- cd08805
Location:1401 → 1484
- Death_ank1; Death domain of Ankyrin-1
- pfam00023
Location:337 → 367
- Ank; Ankyrin repeat
- pfam12796
Location:639 → 730
- Ank_2; Ankyrin repeats (3 copies)
- pfam13637
Location:14 → 65
- Ank_4; Ankyrin repeats (many copies)
- pfam13857
Location:720 → 774
- Ank_5; Ankyrin repeats (many copies)
- sd00045
Location:403 → 434
- ANK; ANK repeat [structural motif]
-
NM_020477.3 → NP_065210.2  ankyrin-1 isoform 2
See identical proteins and their annotated locations for NP_065210.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an in-frame segment near to the 3' coding region, compared to variant 1. The resulting isoform (2, also referred to as isoform 2.2) is therefore shorter than isoform 1.
- Source sequence(s)
-
AB209418, AC113133, AK126647, M28880, N63745, X16609
- UniProtKB/Swiss-Prot
-
P16157
- UniProtKB/TrEMBL
-
B3KX39
- Conserved Domains (10) summary
-
- smart00218
Location:911 → 1015
- ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
- smart00248
Location:601 → 630
- ANK; ankyrin repeats
- COG0666
Location:341 → 554
- ANKYR; Ankyrin repeat [Signal transduction mechanisms]
- cd00204
Location:365 → 490
- ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
- cd08805
Location:1401 → 1484
- Death_ank1; Death domain of Ankyrin-1
- pfam00023
Location:337 → 367
- Ank; Ankyrin repeat
- pfam12796
Location:639 → 730
- Ank_2; Ankyrin repeats (3 copies)
- pfam13637
Location:14 → 65
- Ank_4; Ankyrin repeats (many copies)
- pfam13857
Location:720 → 774
- Ank_5; Ankyrin repeats (many copies)
- sd00045
Location:403 → 434
- ANK; ANK repeat [structural motif]
-
NM_020478.5 → NP_065211.2  ankyrin-1 isoform 5
See identical proteins and their annotated locations for NP_065211.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) lacks multiple 5' exons, but has an alternate 5' exon, which includes an AUG start codon, and it also has an alternate segment in the 3' coding region, which includes a stop codon, compared to variant 1. The resulting isoform (5, also referred to as Ank 1.5 and sAnk1) has a much shorter and distinct N-terminus and also has a distinct C-terminus, compared to isoform 1. This small isoform binds to the C-terminus of obscurin, a giant protein surrounding the contractile apparatus in striated muscle, and the binding may be essential for the proper alignment of the network sarcoplasmic reticulum.
- Source sequence(s)
-
AC113133, AK223578, BC014467, N63745
- Consensus CDS
-
CCDS6122.1
- UniProtKB/Swiss-Prot
-
P16157
- Related
- ENSP00000319123.8, ENST00000314214.12
-
NM_020480.5 → NP_065213.2  ankyrin-1 isoform 7
See identical proteins and their annotated locations for NP_065213.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) lacks multiple 5' exons and an in-frame coding exon in the 3' region, but has an alternate 5' exon which includes an AUG start codon, compared to variant 1. The resulting isoform (7) has a much shorter and distinct N-terminus, and lacks a segment in the C-terminal region, compared to isoform 1.
- Source sequence(s)
-
AC113133, BC014467, BC117121, N63745
- Consensus CDS
-
CCDS6120.1
- UniProtKB/TrEMBL
-
C9JN86
- Related
- ENSP00000297744.5, ENST00000348036.8
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000008.11Â Reference GRCh38.p14 Primary Assembly
- Range
-
41653225..41896741 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060932.1Â Alternate T2T-CHM13v2.0
- Range
-
41926848..42170259 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_020479.2: Suppressed sequence
- Description
- NM_020479.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
-
NM_020481.2: Suppressed sequence
- Description
- NM_020481.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.