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    GPR85 G protein-coupled receptor 85 [ Homo sapiens (human) ]

    Gene ID: 54329, updated on 28-Oct-2024

    Summary

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    Official Symbol
    GPR85provided by HGNC
    Official Full Name
    G protein-coupled receptor 85provided by HGNC
    Primary source
    HGNC:HGNC:4536
    See related
    Ensembl:ENSG00000164604 MIM:605188; AllianceGenome:HGNC:4536
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SREB; SREB2
    Summary
    Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]
    Expression
    Biased expression in brain (RPKM 3.3), testis (RPKM 1.1) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR85 in Genome Data Viewer
    Location:
    7q31.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (113082285..113087724, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (114401309..114406733, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (112722340..112727779, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26517 Neighboring gene S-adenosylmethionine sensor upstream of mTORC1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:112556531-112557032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:112557033-112557532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18545 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:112579888-112580404 Neighboring gene heart tissue-associated transcript 17 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18546 Neighboring gene uncharacterized LOC107986837 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:112758380-112758974 Neighboring gene small integral membrane protein 30 Neighboring gene NANOG hESC enhancer GRCh37_chr7:112828377-112828990 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:112902892-112903479 Neighboring gene NANOG hESC enhancer GRCh37_chr7:113061672-113062194 Neighboring gene uncharacterized LOC124901813

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteers. Radulescu E, et al. Neuropsychopharmacology, 2013 Jan. PMID 22968816, Free PMC Article
    2. Cloning and localization of rgpr85 encoding rat G-protein-coupled receptor. Jeon J, et al. Biochem Biophys Res Commun, 2002 Nov 8. PMID 12408996
    3. The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia. Matsumoto M, et al. Proc Natl Acad Sci U S A, 2008 Apr 22. PMID 18413613, Free PMC Article
    4. The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31. Hellebrand S, et al. Biochim Biophys Acta, 2000 Sep 7. PMID 10978537
    5. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. Matsumoto M, et al. Brain Res Mol Brain Res, 2005 Jul 29. PMID 15893849

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Risk-associated variants in GPR85 are associated with phenotypes similar to those found in patients with schizophrenia.
      Title: Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteers.
    2. Theses data implicate SREB2 as a potential risk factor for psychiatric disorders.
      Title: The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia.
    3. The areas expressing high levels of SREB2 mRNA overlap with brain structures known to possess high levels of plasticity, namely, the hippocampal formation, olfactory system, and supraoptic and paraventricular nuclei.
      Title: A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of G protein-coupled receptor 85 (GPR85) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ50993, FLJ51159, FLJ99433

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 85
    Names
    seven transmembrane helix receptor
    super conserved receptor expressed in brain 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146265.2 → NP_001139737.1  probable G-protein coupled receptor 85

      See identical proteins and their annotated locations for NP_001139737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein.
      Source sequence(s)
      AC073346
      Consensus CDS
      CCDS5758.1
      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2
      Related
      ENSP00000297146.2, ENST00000297146.7
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001146266.2 → NP_001139738.1  probable G-protein coupled receptor 85

      See identical proteins and their annotated locations for NP_001139738.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
      Source sequence(s)
      AC073346
      Consensus CDS
      CCDS5758.1
      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2
      Related
      ENSP00000401178.1, ENST00000449591.2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001146267.2 → NP_001139739.1  probable G-protein coupled receptor 85

      See identical proteins and their annotated locations for NP_001139739.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
      Source sequence(s)
      AC073346
      Consensus CDS
      CCDS5758.1
      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2
      Related
      ENSP00000396763.1, ENST00000424100.2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_018970.7 → NP_061843.3  probable G-protein coupled receptor 85

      See identical proteins and their annotated locations for NP_061843.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
      Source sequence(s)
      AC073346
      Consensus CDS
      CCDS5758.1
      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      113082285..113087724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005250451.3 → XP_005250508.1  probable G-protein coupled receptor 85 isoform X1

      See identical proteins and their annotated locations for XP_005250508.1

      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_017012352.3 → XP_016867841.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      114401309..114406733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358466.1 → XP_054214441.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8

    2. XM_054358465.1 → XP_054214440.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60893.1 GenPept UniProtKB/Swiss-Prot:P60893

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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