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    GPAT4 glycerol-3-phosphate acyltransferase 4 [ Homo sapiens (human) ]

    Gene ID: 137964, updated on 28-Oct-2024

    Summary

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    Official Symbol
    GPAT4provided by HGNC
    Official Full Name
    glycerol-3-phosphate acyltransferase 4provided by HGNC
    Primary source
    HGNC:HGNC:20880
    See related
    Ensembl:ENSG00000158669 MIM:608143; AllianceGenome:HGNC:20880
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AGPAT6; LPAATZ; TSARG7; 1-AGPAT 6; LPAAT-zeta
    Summary
    Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]
    Expression
    Ubiquitous expression in endometrium (RPKM 10.2), adrenal (RPKM 10.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPAT4 in Genome Data Viewer
    Location:
    8p11.21
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (41578200..41625001)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (41851958..41898752)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41435719..41482520)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27287 Neighboring gene GPAT4 and GINS4 antisense RNA 1 Neighboring gene uncharacterized LOC124901939 Neighboring gene GINS complex subunit 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41424977-41425739 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:41430689-41430895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41451733-41452234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41454165-41454665 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:41466108-41467307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27291 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41510853-41511646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41513473-41514006 Neighboring gene NK6 homeobox 3 Neighboring gene microRNA 486-1 Neighboring gene microRNA 486-2 Neighboring gene ankyrin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family. Li D, et al. J Hum Genet, 2003. PMID 12938015
    2. Molecular cloning and preliminary function study of a novel human gene, TSARG7, related to spermatogenesis. Tan XJ, et al. Yi Chuan Xue Bao, 2006 Apr. PMID 16625827
    3. Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes. Snogdal LS, et al. BMC Med Genet, 2013 Oct 25. PMID 24156295, Free PMC Article
    4. GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis. Shan D, et al. J Lipid Res, 2010 Jul. PMID 20181984, Free PMC Article
    5. Glycerol-3-phosphate Acyltransferase Isoform-4 (GPAT4) Limits Oxidation of Exogenous Fatty Acids in Brown Adipocytes. Cooper DE, et al. J Biol Chem, 2015 Jun 12. PMID 25918168, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPAT4 activity requires CHP1 to be N-myristoylated, forming a key molecular interface between the two proteins, regulating glycerolipid metabolism.
      Title: CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4.
    2. None of the eleven AGPAT6 variants were robustly associated with type 2 diabetes in the Danish.
      Title: Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes.
    3. Results reveal a link between the lipogenic effects of insulin and microsomal GPAT3 and GPAT4, implying their importance in glycerolipid biosynthesis.
      Title: GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis.
    4. we have cloned a novel human gene and this gene may play an important role in human spermatogenesis and sexual maturation.
      Title: Molecular cloning and preliminary function study of a novel human gene, TSARG7, related to spermatogenesis.
    5. AGPAT6 is a microsomal GPAT, and we propose renaming this enzyme GPAT4.
      Title: AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp586M1819

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerol-3-phosphate O-acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in diacylglycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glandular epithelial cell maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in triglyceride biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycerol-3-phosphate acyltransferase 4
    Names
    1-AGP acyltransferase 6
    1-acyl-sn-glycerol-3-phosphate acyltransferase zeta
    1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
    glycerol-3-phosphate acyltransferase 6
    lysophosphatidic acid acyltransferase zeta
    testis spermatogenesis apoptosis-related protein 7
    NP_001350126.1
    NP_001350127.1
    NP_848934.1
    XP_047277326.1
    XP_047277327.1
    XP_047277328.1
    XP_047277330.1
    XP_054215737.1
    XP_054215738.1
    XP_054215739.1
    XP_054215740.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363197.2 → NP_001350126.1  glycerol-3-phosphate acyltransferase 4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC009630, AF406612, BU149203, BU620295, DB479618
      Consensus CDS
      CCDS6117.1
      UniProtKB/Swiss-Prot
      Q2TU73, Q86UL3, Q86V89
      Conserved Domains (1) summary
      cd07991
      Location:218 → 427
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    2. NM_001363198.2 → NP_001350127.1  glycerol-3-phosphate acyltransferase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009630, AF406612, BU149203, BU620295
      UniProtKB/TrEMBL
      Q8NDD3

    3. NM_178819.4 → NP_848934.1  glycerol-3-phosphate acyltransferase 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_848934.1

      Status: VALIDATED

      Source sequence(s)
      AC009630, AF406612, BU620295
      Consensus CDS
      CCDS6117.1
      UniProtKB/Swiss-Prot
      Q2TU73, Q86UL3, Q86V89
      Related
      ENSP00000380184.3, ENST00000396987.7
      Conserved Domains (1) summary
      cd07991
      Location:218 → 427
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      41578200..41625001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421370.1 → XP_047277326.1  glycerol-3-phosphate acyltransferase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q2TU73, Q86UL3, Q86V89

    2. XM_047421372.1 → XP_047277328.1  glycerol-3-phosphate acyltransferase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q2TU73, Q86UL3, Q86V89

    3. XM_047421371.1 → XP_047277327.1  glycerol-3-phosphate acyltransferase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q2TU73, Q86UL3, Q86V89

    4. XM_047421374.1 → XP_047277330.1  glycerol-3-phosphate acyltransferase 4 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      41851958..41898752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359762.1 → XP_054215737.1  glycerol-3-phosphate acyltransferase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q2TU73, Q86UL3, Q86V89

    2. XM_054359764.1 → XP_054215739.1  glycerol-3-phosphate acyltransferase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q2TU73, Q86UL3, Q86V89

    3. XM_054359763.1 → XP_054215738.1  glycerol-3-phosphate acyltransferase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q2TU73, Q86UL3, Q86V89

    4. XM_054359765.1 → XP_054215740.1  glycerol-3-phosphate acyltransferase 4 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86UL3.1 GenPept UniProtKB/Swiss-Prot:Q86UL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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