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    TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [ Homo sapiens (human) ]

    Gene ID: 26115, updated on 28-Oct-2024

    Summary

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    Official Symbol
    TANC2provided by HGNC
    Official Full Name
    tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2provided by HGNC
    Primary source
    HGNC:HGNC:30212
    See related
    Ensembl:ENSG00000170921 MIM:615047; AllianceGenome:HGNC:30212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    rols; ROLSA; IDDALDS
    Summary
    Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in dense core granule cytoskeletal transport; regulation of dendritic spine development; and regulation of dendritic spine morphogenesis. Predicted to act upstream of or within in utero embryonic development. Located in dendritic spine. Implicated in intellectual developmental disorder with autistic features and language delay, with or without seizures. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in brain (RPKM 6.5), testis (RPKM 5.9) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TANC2 in Genome Data Viewer
    Location:
    17q23.2-q23.3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (62966235..63427703)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (63836303..64297911)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (61043596..61505064)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8814 Neighboring gene tRNA methyltransferase subunit 11-2 pseudogene 3 Neighboring gene microRNA 633 Neighboring gene Sharpr-MPRA regulatory region 13093 Neighboring gene NANOG hESC enhancer GRCh37_chr17:61122317-61122818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61143140-61143657 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61143658-61144174 Neighboring gene zinc finger protein pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:61259160-61260359 Neighboring gene DNAJB6 pseudogene 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61310050-61310550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61310551-61311051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61382271-61382865 Neighboring gene NANOG hESC enhancer GRCh37_chr17:61423641-61424164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61438304-61438804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61438805-61439305 Neighboring gene DENR pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 4360 Neighboring gene uncharacterized LOC105371856 Neighboring gene Sharpr-MPRA regulatory region 7022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61503073-61503811 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:61512442-61512609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61513919-61514833 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61514834-61515748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61524253-61525066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61525067-61525879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61528047-61528547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61533342-61534200 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61534201-61535059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12545 Neighboring gene cytochrome b561 Neighboring gene peptidylprolyl isomerase A pseudogene 55

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Dynamic scaffolds for neuronal signaling: in silico analysis of the TANC protein family. Gasparini A, et al. Sci Rep, 2017 Jul 28. PMID 28754924, Free PMC Article
    2. Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons. Kim SG, et al. Nat Commun, 2021 May 11. PMID 33976205, Free PMC Article
    3. Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders. Guo H, et al. Nat Commun, 2019 Oct 15. PMID 31616000, Free PMC Article
    4. HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in a PBM-Dependent Manner and Promotes Increased Cell Proliferation. Broniarczyk JK, et al. J Virol, 2022 Nov 23. PMID 36326272, Free PMC Article
    5. A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation. Mahmood SF, et al. Carcinogenesis, 2014 Mar. PMID 24148822

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in a PBM-Dependent Manner and Promotes Increased Cell Proliferation.
      Title: HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in a PBM-Dependent Manner and Promotes Increased Cell Proliferation.
    2. Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons.
      Title: Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons.
    3. Pediatric patients with disruptive TANC2 mutations present with autism, intellectual disability, and delayed language and motor development. In addition to a variable degree of epilepsy and facial dysmorphism, we observe a pattern of more complex psychiatric dysfunction or behavioral problems in adult probands or carrier parents.
      Title: Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders.
    4. -RAD21 and EIF3H, both on chromosome 8q23, CHRAC1 on chromosome 8q24.3 and TANC2 on chromosome 17q23-were confirmed to be driver genes regulating the proliferation/survival of clonogenic breast cancer cells
      Title: A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation.
    5. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
      Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10215, FLJ11824, KIAA1148, KIAA1636, DKFZp564D166

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in dense core granule cytoskeletal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein TANC2
    Names
    putative ankyrin-repeat containing protein
    rolling pebbles homolog B
    tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394998.1 → NP_001381927.1  protein TANC2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC005828, AC005972, AC006270, AC015923
      Consensus CDS
      CCDS92376.1
      UniProtKB/TrEMBL
      A0A8I5KXR5
      Related
      ENSP00000510600.1, ENST00000689528.1
      Conserved Domains (6) summary
      PHA03095
      Location:930 → 1224
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1511 → 1740
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1324 → 1459
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1170 → 1296
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1331 → 1356
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]

    2. NM_001411076.1 → NP_001398005.1  protein TANC2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC005828, AC005972, AC006270, AC015923
      Consensus CDS
      CCDS92375.1
      Related
      ENSP00000374171.4, ENST00000389520.8

    3. NM_025185.4 → NP_079461.2  protein TANC2 isoform 1

      See identical proteins and their annotated locations for NP_079461.2

      Status: VALIDATED

      Source sequence(s)
      AC005828, AC005972, AC006270, AC015923
      Consensus CDS
      CCDS45754.1
      UniProtKB/Swiss-Prot
      Q9HAC3, Q9HCD6, Q9NW88, Q9NXY9, Q9ULS2
      Related
      ENSP00000387593.2, ENST00000424789.6
      Conserved Domains (10) summary
      cd00204
      Location:1094 → 1219
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:1247 → 1272
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:1402 → 1629
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:1104 → 1196
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:1427 → 1498
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:341 → 383
      AAA_16; AAA ATPase domain
      pfam13414
      Location:1293 → 1356
      TPR_11; TPR repeat
      pfam13428
      Location:1326 → 1368
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:888 → 937
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1100 → 1130
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      62966235..63427703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524597.3 → XP_011522899.1  protein TANC2 isoform X1

      Conserved Domains (9) summary
      cd00204
      Location:1168 → 1293
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:1331 → 1356
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:1487 → 1714
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:1178 → 1270
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:1512 → 1583
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:415 → 457
      AAA_16; AAA ATPase domain
      pfam13414
      Location:1377 → 1441
      TPR_11; TPR repeat
      pfam13637
      Location:962 → 1011
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]

    2. XM_006721810.4 → XP_006721873.1  protein TANC2 isoform X16

      UniProtKB/TrEMBL
      J3KRP9
      Conserved Domains (5) summary
      cd00204
      Location:1168 → 1293
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:1178 → 1270
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:415 → 457
      AAA_16; AAA ATPase domain
      pfam13637
      Location:962 → 1011
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]

    3. XM_011524598.3 → XP_011522900.1  protein TANC2 isoform X2

      Conserved Domains (9) summary
      cd00204
      Location:1168 → 1293
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:1321 → 1346
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:1477 → 1704
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:1178 → 1270
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:1502 → 1573
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:415 → 457
      AAA_16; AAA ATPase domain
      pfam13414
      Location:1367 → 1431
      TPR_11; TPR repeat
      pfam13637
      Location:962 → 1011
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]

    4. XM_006721807.4 → XP_006721870.1  protein TANC2 isoform X3

      Conserved Domains (10) summary
      cd00204
      Location:1168 → 1293
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:1321 → 1346
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:1476 → 1703
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:1178 → 1270
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:1501 → 1572
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:415 → 457
      AAA_16; AAA ATPase domain
      pfam13414
      Location:1367 → 1430
      TPR_11; TPR repeat
      pfam13428
      Location:1400 → 1442
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:962 → 1011
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]

    5. XM_006721811.5 → XP_006721874.1  protein TANC2 isoform X17

      UniProtKB/TrEMBL
      J3KRP9
      Conserved Domains (5) summary
      cd00204
      Location:1168 → 1293
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:1178 → 1270
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:415 → 457
      AAA_16; AAA ATPase domain
      pfam13637
      Location:962 → 1011
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]

    6. XM_011524600.3 → XP_011522902.1  protein TANC2 isoform X6

      Conserved Domains (9) summary
      cd00204
      Location:1131 → 1256
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:1294 → 1319
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:1450 → 1677
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:1141 → 1233
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:1475 → 1546
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:378 → 420
      AAA_16; AAA ATPase domain
      pfam13414
      Location:1340 → 1404
      TPR_11; TPR repeat
      pfam13637
      Location:925 → 974
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1137 → 1167
      ANK; ANK repeat [structural motif]

    7. XM_047435731.1 → XP_047291687.1  protein TANC2 isoform X8

    8. XM_047435733.1 → XP_047291689.1  protein TANC2 isoform X10

    9. XM_047435734.1 → XP_047291690.1  protein TANC2 isoform X11

    10. XM_047435738.1 → XP_047291694.1  protein TANC2 isoform X18

      Related
      ENSP00000462109.1, ENST00000583356.5

    11. XM_011524601.3 → XP_011522903.1  protein TANC2 isoform X7

      Conserved Domains (9) summary
      cd00204
      Location:1131 → 1256
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:1294 → 1319
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:1450 → 1677
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:1141 → 1233
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:1475 → 1546
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:378 → 420
      AAA_16; AAA ATPase domain
      pfam13414
      Location:1340 → 1404
      TPR_11; TPR repeat
      pfam13637
      Location:925 → 974
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1137 → 1167
      ANK; ANK repeat [structural motif]

    12. XM_047435732.1 → XP_047291688.1  protein TANC2 isoform X9

    13. XM_011524602.3 → XP_011522904.1  protein TANC2 isoform X13

      Conserved Domains (9) summary
      cd00204
      Location:1094 → 1219
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:1257 → 1282
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:1413 → 1640
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:1104 → 1196
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:1438 → 1509
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:341 → 383
      AAA_16; AAA ATPase domain
      pfam13414
      Location:1303 → 1367
      TPR_11; TPR repeat
      pfam13637
      Location:888 → 937
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1100 → 1130
      ANK; ANK repeat [structural motif]

    14. XM_011524599.2 → XP_011522901.1  protein TANC2 isoform X4

      Conserved Domains (9) summary
      cd00204
      Location:1152 → 1277
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:1315 → 1340
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:1471 → 1698
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:1162 → 1254
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:1496 → 1567
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:399 → 441
      AAA_16; AAA ATPase domain
      pfam13414
      Location:1361 → 1425
      TPR_11; TPR repeat
      pfam13637
      Location:946 → 995
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1158 → 1188
      ANK; ANK repeat [structural motif]

    15. XM_017024429.2 → XP_016879918.1  protein TANC2 isoform X5

    16. XM_047435735.1 → XP_047291691.1  protein TANC2 isoform X12

    17. XM_047435737.1 → XP_047291693.1  protein TANC2 isoform X14

    18. XM_017024430.3 → XP_016879919.1  protein TANC2 isoform X15

      Conserved Domains (9) summary
      cd00204
      Location:1004 → 1129
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:1167 → 1192
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:1323 → 1550
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:1014 → 1106
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:1348 → 1419
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:251 → 293
      AAA_16; AAA ATPase domain
      pfam13414
      Location:1213 → 1277
      TPR_11; TPR repeat
      pfam13637
      Location:798 → 847
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1010 → 1040
      ANK; ANK repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      63836303..64297911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315677.1 → XP_054171652.1  protein TANC2 isoform X1

    2. XM_054315678.1 → XP_054171653.1  protein TANC2 isoform X2

    3. XM_054315682.1 → XP_054171657.1  protein TANC2 isoform X6

    4. XM_054315686.1 → XP_054171661.1  protein TANC2 isoform X10

    5. XM_054315683.1 → XP_054171658.1  protein TANC2 isoform X7

    6. XM_054315689.1 → XP_054171664.1  protein TANC2 isoform X13

    7. XM_054315692.1 → XP_054171667.1  protein TANC2 isoform X16

    8. XM_054315679.1 → XP_054171654.1  protein TANC2 isoform X3

    9. XM_054315693.1 → XP_054171668.1  protein TANC2 isoform X17

    10. XM_054315684.1 → XP_054171659.1  protein TANC2 isoform X8

    11. XM_054315687.1 → XP_054171662.1  protein TANC2 isoform X11

    12. XM_054315694.1 → XP_054171669.1  protein TANC2 isoform X18

    13. XM_054315685.1 → XP_054171660.1  protein TANC2 isoform X9

    14. XM_054315680.1 → XP_054171655.1  protein TANC2 isoform X4

    15. XM_054315688.1 → XP_054171663.1  protein TANC2 isoform X12

    16. XM_054315690.1 → XP_054171665.1  protein TANC2 isoform X14

    17. XM_054315681.1 → XP_054171656.1  protein TANC2 isoform X5

    18. XM_054315691.1 → XP_054171666.1  protein TANC2 isoform X15

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_015623.2: Suppressed sequence

      Description
      NM_015623.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.

    2. NM_030658.2: Suppressed sequence

      Description
      NM_030658.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HCD6.3 GenPept UniProtKB/Swiss-Prot:Q9HCD6

    Gene LinkOut

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