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    RPL22L1 ribosomal protein L22 like 1 [ Homo sapiens (human) ]

    Gene ID: 200916, updated on 17-Jun-2024

    Summary

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    Official Symbol
    RPL22L1provided by HGNC
    Official Full Name
    ribosomal protein L22 like 1provided by HGNC
    Primary source
    HGNC:HGNC:27610
    See related
    Ensembl:ENSG00000163584 AllianceGenome:HGNC:27610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to be located in ribosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 15.2), appendix (RPKM 13.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RPL22L1 in Genome Data Viewer
    Location:
    3q26.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (170864875..170870195, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (173649212..173654530, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (170582664..170587984, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374211 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:170535382-170535959 Neighboring gene NANOG hESC enhancer GRCh37_chr3:170553092-170553655 Neighboring gene MPRA-validated peak4920 silencer Neighboring gene RNY5 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20807 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:170587696-170588422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:170588423-170589148 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:170601523-170602103 Neighboring gene eukaryotic translation initiation factor 5A2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14888 Neighboring gene KLF7 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Ribosomal protein L22-like1 promotes prostate cancer progression by activating PI3K/Akt/mTOR signalling pathway. Yi X, et al. J Cell Mol Med, 2023 Feb. PMID 36625246, Free PMC Article
    2. RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance. Rao S, et al. PLoS One, 2019. PMID 31581233, Free PMC Article
    3. Identification of the BRD1 interaction network and its impact on mental disorder risk. Fryland T, et al. Genome Med, 2016 May 3. PMID 27142060, Free PMC Article
    4. The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. Matoba R, et al. Gene, 1994 Sep 2. PMID 8076819
    5. Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal. Du L, et al. Nat Commun, 2016 Jul 28. PMID 27465491, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ribosomal protein L22-like1 promotes prostate cancer progression by activating PI3K/Akt/mTOR signalling pathway.
      Title: Ribosomal protein L22-like1 promotes prostate cancer progression by activating PI3K/Akt/mTOR signalling pathway.
    2. RPL22L1 might be a prognostic marker in colorectal cancer and predict 5-Fluorouracil responsiveness.
      Title: RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC104449

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein eL22-like
    Names
    60S ribosomal protein L22-like 1
    large ribosomal subunit protein eL22-like 1
    NP_001093115.1
    NP_001307380.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099645.2 → NP_001093115.1  ribosomal protein eL22-like isoform 1

      See identical proteins and their annotated locations for NP_001093115.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1),
      Source sequence(s)
      AC061708, BC062731, CA449264
      Consensus CDS
      CCDS46955.1
      UniProtKB/Swiss-Prot
      Q32Q77, Q6P5R6
      UniProtKB/TrEMBL
      H0Y8C2
      Related
      ENSP00000346080.7, ENST00000295830.13
      Conserved Domains (1) summary
      pfam01776
      Location:16 → 113
      Ribosomal_L22e; Ribosomal L22e protein family

    2. NM_001320451.2 → NP_001307380.1  ribosomal protein eL22-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC061708, BU540139, CA449264
      Consensus CDS
      CCDS82875.1
      UniProtKB/TrEMBL
      C9JYQ9, H0Y8C2
      Related
      ENSP00000419041.1, ENST00000463836.1
      Conserved Domains (1) summary
      pfam01776
      Location:15 → 112
      Ribosomal_L22e; Ribosomal L22e protein family

    RNA

    1. NR_135259.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site, in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5' most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC061708, AL110170, BM451642, CA449264

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      170864875..170870195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      173649212..173654530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P5R6.2 GenPept UniProtKB/Swiss-Prot:Q6P5R6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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