STK10 serine/threonine kinase 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STK10provided by HGNC
Official Full Name: serine/threonine kinase 10provided by HGNC
Primary source: HGNC:HGNC:11388
See related: Ensembl:ENSG00000072786 MIM:603919; AllianceGenome:HGNC:11388
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LOK; PRO2729
Summary: This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]
Expression: Broad expression in spleen (RPKM 23.3), bone marrow (RPKM 21.8) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q35.1

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (172042079..172188224, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (172582378..172728531, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (171469083..171615228, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia.
Title: Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia.
Binding of phosphatidylinositol 4,5-biphosphate to ezrin induces a conformational change permitting the insertion of the LOK C-terminal domain to wedge apart the membrane and F-actin-binding domains of ezrin. The N-terminal LOK kinase domain can then access a site 40 residues distal from the consensus sequence that collectively direct phosphorylation of the appropriate threonine residue.
Title: Ezrin activation by LOK phosphorylation involves a PIP(2)-dependent wedge mechanism.
The gene signature of OPA1, CTSA, NDUFA1, STK10 and PRDX1 was able to identify patients post-implant with a sensitivity of 91% and a specificity of 86% in discrimination between post-implant group and healthy controls.
Title: Altered mitochondrial expression genes in patients receiving right ventricular apical pacing.
STK10 functions as a tumor suppressor gene, and dysfunction of STK10 activity either through polymorphism or somatic mutations may confer anti-apoptotic effects contributing to carcinogenesis.
Title: STK10 missense mutations associated with anti-apoptotic function.
It was shown that lymphocyte-oriented and STE20 kinase were sufficient to restrict ezrin function to the apical domain. Both kinases were enriched in microvilli and locally activated there.
Title: Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.
genetic polymorphism is associated with aspirin-intolerant asthma in a Korean population
Title: Variations in the STK10 gene and possible associations with aspirin-intolerant asthma in a Korean population.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: A three-stage genome-wide association study of general cognitive ability: hunting the small effects.
These studies identify a new ERM kinase of importance in lymphocytes and confirm the role of ezrin-radixin-moesin phosphorylation in regulating cell shape and motility.
Title: LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.
Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells
Title: Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STK10 (e-PCR)
- UniSTS:504845

bac51876S (e-PCR)
- UniSTS:181521

D5S604 (e-PCR)
- UniSTS:58656

D5S425 (e-PCR), detects polymorphism
- UniSTS:35879

RH79031 (e-PCR)
- UniSTS:39217

SHGC-156055 (e-PCR)
- UniSTS:184188

RH48725 (e-PCR)
- UniSTS:7823

G60365 (e-PCR)
- UniSTS:137621

D5S1960 (e-PCR), detects polymorphism
- UniSTS:49306

STS-W58187 (e-PCR)
- UniSTS:63906

D5S1383 (e-PCR)
- UniSTS:149192

SHGC-150661 (e-PCR)
- UniSTS:173276

L28383 (e-PCR)
- UniSTS:14305

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lymphocyte aggregation	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	TAS Traceable Author Statement more info
involved_in regulation of lymphocyte migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lymphocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in specific granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: serine/threonine-protein kinase 10

Names: lymphocyte-oriented kinase

NP_005981.3

EC 2.7.11.1

XP_047273583.1

EC 2.7.11.1

XP_047273584.1

EC 2.7.11.1

XP_047273585.1

EC 2.7.11.1

XP_054209287.1

EC 2.7.11.1

XP_054209288.1

EC 2.7.11.1

XP_054209289.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005990.4 → NP_005981.3 serine/threonine-protein kinase 10

See identical proteins and their annotated locations for NP_005981.3

Status: REVIEWED

Source sequence(s)

AB015718, AC113342, AI584023, BI459912, DA507768, DB068209

Consensus CDS

CCDS34290.1

UniProtKB/Swiss-Prot

A6ND35, B2R8F5, B3KMY1, O94804, Q6NSK0, Q9UIW4

Related

ENSP00000176763.5, ENST00000176763.10

Conserved Domains (3) summary

cd06644
Location:23 → 314

STKc_STK10; Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK)

smart00220
Location:36 → 294

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam12474
Location:755 → 895

PKK; Polo kinase kinase