GRB7 growth factor receptor bound protein 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GRB7provided by HGNC
Official Full Name: growth factor receptor bound protein 7provided by HGNC
Primary source: HGNC:HGNC:4567
See related: Ensembl:ENSG00000141738 MIM:601522; AllianceGenome:HGNC:4567
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Expression: Broad expression in kidney (RPKM 6.4), esophagus (RPKM 5.5) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (39737938..39747285)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (40601500..40610848)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (37894191..37903538)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRB7 plays a promoting role in the progression of gastric cancer.
Title: GRB7 plays a promoting role in the progression of gastric cancer.
Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells.
Title: Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells.
Upregulated GRB7 promotes proliferation and tumorigenesis of Bladder Cancer via Phospho-AKT Pathway.
Title: Upregulated GRB7 promotes proliferation and tumorigenesis of Bladder Cancer via Phospho-AKT Pathway.
Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling.
Title: Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling.
GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma.
Title: GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma.
In vitro phosphorylation of the Grb7SH2 domain indicates only one of the available tyrosine residues is phosphorylated, suggesting the same phosphorylation pattern could be relevant in the full length protein.
Title: Characterization of the full-length human Grb7 protein and a phosphorylation representative mutant.
this is a review about the molecular, functional, and clinical aspects of Grb7 in erythroblastic leukemia viral oncogene homolog family-mediated cancer family-mediated cancer development and malignancy with the aim to reveal alternative and effective therapeutic strategies.[review]
Title: Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic Target.
It was identified that silencing of miR193a3p through hypermethylation can promote HER2 positive breast cancer progress by targeting GRB7, ERK1/2 and FOXM1 signaling.
Title: Epigenetically altered miR‑193a‑3p promotes HER2 positive breast cancer aggressiveness by targeting GRB7.
MiR-193a-3p not only modulated GRB7 but also ERBB4.
Title: Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways.
Our results indicated that Grb7 over-expression may facilitate invasion and inhibit apoptosis in cervical cancer
Title: Grb7 is over-expressed in cervical cancer and facilitate invasion and inhibit apoptosis in cervical cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-9366 (e-PCR)
- UniSTS:31258

GRB7_4323 (e-PCR)
- UniSTS:462897

STS-D43772 (e-PCR)
- UniSTS:30718

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in epidermal growth factor receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
NOT involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in negative regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in stress granule assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: growth factor receptor-bound protein 7

Names: B47; GRB7 adapter protein; epidermal growth factor receptor GRB-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029932.2 RefSeqGene

Range

5002..14349

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001030002.3 → NP_001025173.1 growth factor receptor-bound protein 7 isoform a

See identical proteins and their annotated locations for NP_001025173.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AC079199

Consensus CDS

CCDS11345.1

UniProtKB/Swiss-Prot

B2RAV1, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q14451, Q53YD3, Q92568, Q96DF9, Q9Y220

UniProtKB/TrEMBL

A0A0S2Z4F6

Related

ENSP00000377761.3, ENST00000394211.7

Conserved Domains (4) summary

cd01787
Location:100 → 184

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10413
Location:425 → 532

SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins

cd01259
Location:225 → 347

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:366 → 410

BPS; BPS (Between PH and SH2)
NM_001242442.2 → NP_001229371.2 growth factor receptor-bound protein 7 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4) encodes the longest isoform (b).

Source sequence(s)

AC079199

Consensus CDS

CCDS56028.1

Related

ENSP00000403459.2, ENST00000445327.6

Conserved Domains (4) summary

cd10413
Location:448 → 555

SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins

cd01259
Location:248 → 370

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16140
Location:123 → 210

RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7

pfam08947
Location:389 → 433

BPS; BPS (Between PH and SH2)
NM_001242443.2 → NP_001229372.1 growth factor receptor-bound protein 7 isoform a

See identical proteins and their annotated locations for NP_001229372.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AC079199

Consensus CDS

CCDS11345.1

UniProtKB/Swiss-Prot

B2RAV1, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q14451, Q53YD3, Q92568, Q96DF9, Q9Y220

UniProtKB/TrEMBL

A0A0S2Z4F6

Related

ENSP00000377759.2, ENST00000394209.6

Conserved Domains (4) summary

cd01787
Location:100 → 184

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10413
Location:425 → 532

SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins

cd01259
Location:225 → 347

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:366 → 410

BPS; BPS (Between PH and SH2)
NM_001330207.2 → NP_001317136.1 growth factor receptor-bound protein 7 isoform c

Status: REVIEWED

Source sequence(s)

AC079199, BC006535

Consensus CDS

CCDS82116.1

UniProtKB/Swiss-Prot

Q14451

Related

ENSP00000377754.1, ENST00000394204.1

Conserved Domains (3) summary

cd01787
Location:100 → 184

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd01259
Location:225 → 347

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:366 → 410

BPS; BPS (Between PH and SH2)
NM_005310.5 → NP_005301.2 growth factor receptor-bound protein 7 isoform a

See identical proteins and their annotated locations for NP_005301.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AC079199

Consensus CDS

CCDS11345.1

UniProtKB/Swiss-Prot

B2RAV1, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q14451, Q53YD3, Q92568, Q96DF9, Q9Y220

UniProtKB/TrEMBL

A0A0S2Z4F6

Related

ENSP00000310771.4, ENST00000309156.9

Conserved Domains (4) summary

cd01787
Location:100 → 184

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10413
Location:425 → 532

SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins

cd01259
Location:225 → 347

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:366 → 410

BPS; BPS (Between PH and SH2)