SESN2 sestrin 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SESN2provided by HGNC
Official Full Name: sestrin 2provided by HGNC
Primary source: HGNC:HGNC:20746
See related: Ensembl:ENSG00000130766 MIM:607767; AllianceGenome:HGNC:20746
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HI95; SES2; SEST2
Summary: This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 15.0), kidney (RPKM 10.3) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p35.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (28259518..28282491)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (28101353..28124325)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (28586029..28609002)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SETDB1 targeting SESN2 regulates mitochondrial damage and oxidative stress in renal ischemia-reperfusion injury.
Title: SETDB1 targeting SESN2 regulates mitochondrial damage and oxidative stress in renal ischemia-reperfusion injury.
Sestrin2 Protects Human Lens Epithelial Cells (HLECs) Against Apoptosis in Cataracts Formation: Interaction Between Endoplasmic Reticulum (ER) Stress and Oxidative Stress (OS) is Involved.
Title: Sestrin2 Protects Human Lens Epithelial Cells (HLECs) Against Apoptosis in Cataracts Formation: Interaction Between Endoplasmic Reticulum (ER) Stress and Oxidative Stress (OS) is Involved.
Sestrin2 ameliorates diabetic retinopathy by regulating autophagy and ferroptosis.
Title: Sestrin2 ameliorates diabetic retinopathy by regulating autophagy and ferroptosis.
Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion.
Title: Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion.
Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.
Title: Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.
Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation.
Title: Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation.
Significance of serum sestrin2 as a biomarker of severity and functional outcome in acute intracerebral hemorrhage: a prospective observational longitudinal study.
Title: Significance of serum sestrin2 as a biomarker of severity and functional outcome in acute intracerebral hemorrhage: a prospective observational longitudinal study.
Serum sestrin 2 levels in patients with uterine leiomyomas.
Title: Serum sestrin 2 levels in patients with uterine leiomyomas.
SESN2 Could Be a Potential Marker for Diagnosis and Prognosis in Glioma.
Title: SESN2 Could Be a Potential Marker for Diagnosis and Prognosis in Glioma.
Sestrin2 suppresses ferroptosis to alleviate septic intestinal inflammation and barrier dysfunction.
Title: Sestrin2 suppresses ferroptosis to alleviate septic intestinal inflammation and barrier dysfunction.

Submit: New GeneRIF Correction See all GeneRIFs (106)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12617 (e-PCR)
- UniSTS:46616

D1S1788E (e-PCR)
- UniSTS:42009

SHGC-74473 (e-PCR)
- UniSTS:25885

D1S1786E (e-PCR)
- UniSTS:15143

D1S2365 (e-PCR)
- UniSTS:20057

D1S1445 (e-PCR)
- UniSTS:149641

A001Z14 (e-PCR)
- UniSTS:28862

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info
enables L-leucine binding	IBA Inferred from Biological aspect of Ancestor more info
enables L-leucine binding	IDA Inferred from Direct Assay more info	PubMed
enables PH domain binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on peroxide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein sequestering activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables sulfiredoxin activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfiredoxin activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in D-glucose import	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in cellular oxidant detoxification	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular oxidant detoxification	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular oxidant detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to L-leucine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to L-leucine	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to L-leucine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to leucine starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to leucine starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to leucine starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial DNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translation in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipophagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reactive oxygen species metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of response to reactive oxygen species	IEA Inferred from Electronic Annotation more info
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Atg1/ULK1 kinase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of TORC2 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of nucleotide-activated protein kinase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sestrin-2

Names: hypoxia induced gene 95; hypoxia-induced

NP_113647.1

EC 1.11.1.15

XP_047287475.1

EC 1.11.1.15

XP_054188131.1

EC 1.11.1.15

XP_054194956.1

EC 1.11.1.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.