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    PLK2 polo like kinase 2 [ Homo sapiens (human) ]

    Gene ID: 10769, updated on 3-Nov-2024

    Summary

    Official Symbol
    PLK2provided by HGNC
    Official Full Name
    polo like kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:19699
    See related
    Ensembl:ENSG00000145632 MIM:607023; AllianceGenome:HGNC:19699
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNK; hSNK; hPlk2
    Summary
    The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Broad expression in spleen (RPKM 41.3), placenta (RPKM 28.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See PLK2 in Genome Data Viewer
    Location:
    5q11.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (58453982..58460086, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (59272431..59278533, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (57749809..57755913, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378983 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:57555313-57556512 Neighboring gene MPRA-validated peak5254 silencer Neighboring gene uncharacterized LOC105378984 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:57702094-57702742 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:57741340-57742539 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86531 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:57752058-57753257 Neighboring gene Sharpr-MPRA regulatory region 13863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22583 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86533 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86555 Neighboring gene GRB2 binding adaptor protein, transmembrane Neighboring gene microRNA 548ae-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP-dependent protein binding PubMed 
    enables protein binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle PubMed 
    involved_in Rap protein signal transduction  
    involved_in Ras protein signal transduction  
    involved_in long-term synaptic depression  
    involved_in long-term synaptic potentiation  
    involved_in memory  
    involved_in mitotic spindle organization  
    involved_in mitotic spindle organization PubMed 
    involved_in mitotic spindle organization  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process in bone marrow cell  
    involved_in negative regulation of cellular senescence  
    involved_in negative regulation of inflammatory response to antigenic stimulus  
    involved_in peptidyl-serine phosphorylation PubMed 
    involved_in positive regulation of autophagy PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of cell migration involved in sprouting angiogenesis  
    involved_in positive regulation of protein catabolic process PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in regulation of centriole replication PubMed 
    involved_in regulation of centriole replication PubMed 
    involved_in regulation of synaptic plasticity  
    involved_in regulation of synaptic plasticity  
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    is_active_in centriole  
    located_in centriole PubMed 
    is_active_in centrosome  
    located_in centrosome PubMed 
    located_in chromatin  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in dendrite  
    is_active_in kinetochore  
    is_active_in nucleus  
    is_active_in spindle pole  

    General protein information

    Preferred Names
    serine/threonine-protein kinase PLK2
    Names
    PLK-2
    serine/threonine-protein kinase SNK
    serum-inducible kinase
    NP_001239155.1
    NP_006613.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252226.2NP_001239155.1  serine/threonine-protein kinase PLK2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced in the 5' region compared to variant 1, however, it maintains the reading frame and encodes a shorter isoform (2) missing a 14 aa protein segment compared to isoform 1.
      Source sequence(s)
      AA954432, AK027851, BC013879, N66865
      Consensus CDS
      CCDS75250.1
      UniProtKB/TrEMBL
      A0A087WUH9
      Related
      ENSP00000478685.1, ENST00000617412.1
      Conserved Domains (4) summary
      smart00220
      Location:68320
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13117
      Location:587668
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:489574
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14188
      Location:66320
      STKc_PLK2; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2
    2. NM_006622.4NP_006613.2  serine/threonine-protein kinase PLK2 isoform 1

      See identical proteins and their annotated locations for NP_006613.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
      Source sequence(s)
      AA954432, AK027851, BC013879, N66865
      Consensus CDS
      CCDS3974.1
      UniProtKB/Swiss-Prot
      O60679, Q96CV7, Q9NYY3, Q9UE61
      Related
      ENSP00000274289.3, ENST00000274289.8
      Conserved Domains (3) summary
      cd13117
      Location:601682
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:503588
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14188
      Location:80334
      STKc_PLK2; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      58453982..58460086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      59272431..59278533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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