NSP1 FG-nucleoporin NSP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NSP1
Official Full Name: FG-nucleoporin NSP1
Primary source: SGD:S000003577
Locus tag: YJL041W
See related: AllianceGenome:SGD:S000003577; FungiDB:YJL041W; VEuPathDB:YJL041W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phospholipid binding activity. A structural constituent of nuclear pore. Involved in nucleocytoplasmic transport. Located in nuclear periphery. Part of nuclear pore central transport channel and nuclear pore nuclear basket. Human ortholog(s) of this gene implicated in primary biliary cholangitis and striatonigral degeneration. Orthologous to several human genes including NUP62 (nucleoporin 62). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NSP1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 2

Sequence:: Chromosome: X; NC_001142.9 (365784..368373)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytoplasmic Masking of Hydrophobic Residues of FG Repeats
Title: In-Cell NMR within Budding Yeast Reveals Cytoplasmic Masking of Hydrophobic Residues of FG Repeats.
Nsp1 releases a barrier that otherwise prevents nuclear pore complex passage through the bud neck to daughter cells.
Title: The transmission of nuclear pore complexes to daughter cells requires a cytoplasmic pool of Nsp1.
Nic96 without its N domain binds in vitro to Phe-GLy repeats of the Nsp1-Nup49-Nup57 complex, suggesting how Nic96 could organize a transport module with coiled-coil domains and FG repeats in the central pore channel.
Title: Structural basis of the nic96 subcomplex organization in the nuclear pore channel.
findings show that phenylalanine-mediated inter-repeat interactions cross-link FG-repeat domains into elastic and reversible hydrogels; evidence obtained that such hydrogel formation is required for viability in yeast
Title: FG-rich repeats of nuclear pore proteins form a three-dimensional meshwork with hydrogel-like properties.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear pore	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal small subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	HDA more info	PubMed
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore central transport channel	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore nuclear basket	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FG-nucleoporin NSP1

NP_012494.3

FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

365784..368373

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181474.3 → NP_012494.3 TPA: FG-nucleoporin NSP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012494.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWE3, P14907

UniProtKB/TrEMBL

A6ZPT6, G2WGX7

Conserved Domains (3) summary

PHA03255
Location:61 → 214

PHA03255; BDLF3; Provisional

PTZ00121
Location:289 → 602

PTZ00121; MAEBL; Provisional

pfam05064
Location:620 → 731

Nsp1_C; Nsp1-like C-terminal region