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    LOH1 Loh1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853413, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LOH1
    Official Full Name
    Loh1p
    Primary source
    SGD:S000003575
    Locus tag
    YJL038C
    See related
    AllianceGenome:SGD:S000003575; FungiDB:YJL038C; VEuPathDB:YJL038C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    OSW4
    Summary
    Involved in ascospore wall assembly and chromosome organization. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See LOH1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (375115..375774, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene tRNA-Arg Neighboring gene Irc18p Neighboring gene tRNA-Val

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rfm1, a novel tethering factor required to recruit the Hst1 histone deacetylase for repression of middle sporulation genes. McCord R, et al. Mol Cell Biol, 2003 Mar. PMID 12612074, Free PMC Article
    2. The transcriptional program of sporulation in budding yeast. Chu S, et al. Science, 1998 Oct 23. PMID 9784122
    3. A screen for spore wall permeability mutants identifies a secreted protease required for proper spore wall assembly. Suda Y, et al. PLoS One, 2009 Sep 25. PMID 19779569, Free PMC Article
    4. A highly redundant gene network controls assembly of the outer spore wall in S. cerevisiae. Lin CP, et al. PLoS Genet, 2013. PMID 23966878, Free PMC Article
    5. A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae. Andersen MP, et al. Genetics, 2008 Jul. PMID 18562670, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore wall assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Loh1p
    NP_012496.1
    • Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to adjacent ORF, IRC18/YJL037W, and the irc18 loh1 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants; SWAT-GFP and mCherry fusion proteins localize to the cytosol; proposed role in maintenance of genome integrity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      375115..375774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181472.1 → NP_012496.1  TPA: Loh1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012496.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWE5, P47055
      UniProtKB/TrEMBL
      A6ZPT8, B3LQ73, C7GSR0, C8ZBH5, G2WGY0, N1NZX3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47055.1

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