CYR1 adenylate cyclase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CYR1
Official Full Name: adenylate cyclase
Primary source: SGD:S000003542
Locus tag: YJL005W
See related: AllianceGenome:SGD:S000003542; FungiDB:YJL005W; VEuPathDB:YJL005W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CDC35; FIL1; HSR1; SRA4; TSM0185
Summary: Enables adenylate cyclase activity. Involved in Ras protein signal transduction and adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in endoplasmic reticulum membrane; mitochondrion; and plasma membrane. Orthologous to human PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) and PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CYR1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (425157..431237)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Snf1 Phosphorylates Adenylate Cyclase and Negatively Regulates Protein Kinase A-dependent Transcription in Saccharomyces cerevisiae
Title: Snf1 Phosphorylates Adenylate Cyclase and Negatively Regulates Protein Kinase A-dependent Transcription in Saccharomyces cerevisiae.
Adenylate cyclase activity does not influence the Ras2 activation state and is required for the proper interaction between Ras2 and the Ira proteins.
Title: Evidence for adenylate cyclase as a scaffold protein for Ras2-Ira interaction in Saccharomyces cerevisie.
Protein coding and expression variation of CYR1 enhances the formation of colony biofilms.
Title: The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae.
Gpa2 relieves the inhibition imposed by the kelch-repeat proteins on Protein Kinase A (PKA), thereby bypassing adenylate cyclase for direct regulation of PKA.
Title: Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cAMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adenylate cyclase

NP_012529.3

EC 4.6.1.1

Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; scaffold protein for Ras2-Ira interaction; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

425157..431237

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181439.3 → NP_012529.3 TPA: adenylate cyclase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012529.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWH0, P08678

UniProtKB/TrEMBL

N1NZZ2

Conserved Domains (6) summary

smart00044
Location:1613 → 1825

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

PLN00113
Location:792 → 1273

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:888 → 910

LRR_RI; leucine-rich repeat [structural motif]

cd01775
Location:678 → 776

RA_PHLPP_like; Ras-associating (RA) domain found in PH domain leucine-rich repeat-containing protein phosphatases, fungal adenylate cyclase, and similar proteins

pfam08509
Location:368 → 418

Ad_cyc_g-alpha; Adenylate cyclase G-alpha binding domain

pfam00481
Location:1374 → 1617

PP2C; Protein phosphatase 2C