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    DBP3 RNA-dependent ATPase DBP3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852802, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DBP3
    Official Full Name
    RNA-dependent ATPase DBP3
    Primary source
    SGD:S000003046
    Locus tag
    YGL078C
    See related
    AllianceGenome:SGD:S000003046; FungiDB:YGL078C; VEuPathDB:YGL078C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA helicase activity. Involved in endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human DDX5 (DEAD-box helicase 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DBP3 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (360288..361859, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene pyruvate transporter MPC1 Neighboring gene Kxd1p Neighboring gene Hnm1p Neighboring gene ribosomal 60S subunit protein L7A Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Bayesian networks approach for predicting protein-protein interactions from genomic data. Jansen R, et al. Science, 2003 Oct 17. PMID 14564010
    2. Dbp3p, a putative RNA helicase in Saccharomyces cerevisiae, is required for efficient pre-rRNA processing predominantly at site A3. Weaver PL, et al. Mol Cell Biol, 1997 Mar. PMID 9032262, Free PMC Article
    3. RNA helicase-mediated regulation of snoRNP dynamics on pre-ribosomes and rRNA 2'-O-methylation. Aquino GRR, et al. Nucleic Acids Res, 2021 Apr 19. PMID 33721027, Free PMC Article
    4. Epigenetic memory independent of symmetric histone inheritance. Saxton DS, et al. Elife, 2019 Oct 15. PMID 31613222, Free PMC Article
    5. Differential RNA-dependent ATPase activities of four rRNA processing yeast DEAD-box proteins. Garcia I, et al. Biochemistry, 2008 Nov 25. PMID 18975973, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on RNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-dependent ATPase DBP3
    NP_011437.3
    • RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      360288..361859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180943.3 → NP_011437.3  TPA: RNA-dependent ATPase DBP3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011437.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU66, P20447
      UniProtKB/TrEMBL
      C7GW37, N1P1V8
      Conserved Domains (1) summary
      COG0513
      Location:88 → 519
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20447.2

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