DOC1 anaphase promoting complex subunit DOC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DOC1
Official Full Name: anaphase promoting complex subunit DOC1
Primary source: SGD:S000003209
Locus tag: YGL240W
See related: AllianceGenome:SGD:S000003209; FungiDB:YGL240W; VEuPathDB:YGL240W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: APC10
Summary: Enables enzyme regulator activity. Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process; chromatin assembly; and positive regulation of ubiquitin protein ligase activity. Located in mitochondrion. Part of anaphase-promoting complex. Orthologous to human ANAPC10 (anaphase promoting complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DOC1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (48613..49365)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The anaphase-promoting complex/cyclosome (APC/C) is suppressed by the small pseudosubstrate inhibitor Acm1. Acm1 D-box extension inhibits reaction processivity by perturbing the normal interaction with Doc1/Apc10. These results reveal a simple, elegant mode of pseudosubstrate inhibition that combines high-affinity activator binding with specific disruption of Doc1/Apc10 function in processive ubiquitylation.
Title: The pseudosubstrate inhibitor Acm1 inhibits the anaphase-promoting complex/cyclosome by combining high-affinity activator binding with disruption of Doc1/Apc10 function.
Formation of a complete APC/C-activator-substrate complex leads to a major enhancement of E2 efficiency.
Title: Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency.
Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7.
Title: Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7.
Doc1 contributes to recognition of the substrate destruction box by the anaphase-promoting complex.
Title: The APC subunit Doc1 promotes recognition of the substrate destruction box.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables enzyme regulator activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in anaphase-promoting complex-dependent catabolic process	IEA Inferred from Electronic Annotation more info
involved_in anaphase-promoting complex-dependent catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein K11-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of anaphase-promoting complex	IDA Inferred from Direct Assay more info	PubMed
part_of anaphase-promoting complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: anaphase promoting complex subunit DOC1

NP_011274.2

Processivity factor; required for ubiquitination activity of anaphase promoting complex (APC), mediates the activity of APC by contributing to substrate recognition; involved in cyclin proteolysis; contains conserved DOC1 homology domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

48613..49365

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181106.1 → NP_011274.2 TPA: anaphase promoting complex subunit DOC1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011274.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VV95, P53068

UniProtKB/TrEMBL

A6ZTV1, B3LHT2, C7GNY6, G2WDM0, N1P204

Conserved Domains (1) summary

COG5156
Location:59 → 248

DOC1; Anaphase-promoting complex (APC), subunit 10 [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones]