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    HIS7 imidazoleglycerol-phosphate synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852550, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HIS7
    Official Full Name
    imidazoleglycerol-phosphate synthase
    Primary source
    SGD:S000000452
    Locus tag
    YBR248C
    See related
    AllianceGenome:SGD:S000000452; FungiDB:YBR248C; VEuPathDB:YBR248C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glutaminase activity and imidazoleglycerol-phosphate synthase activity. Involved in histidine biosynthetic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HIS7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (714807..716465, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene diphthamide synthase Neighboring gene snoRNA-binding rRNA-processing protein ENP1 Neighboring gene 3-deoxy-7-phosphoheptulonate synthase ARO4 Neighboring gene Spo23p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A network of conserved interactions regulates the allosteric signal in a glutamine amidotransferase. Amaro RE, et al. Biochemistry, 2007 Feb 27. PMID 17261030
    2. The adjacent yeast genes ARO4 and HIS7 carry no intergenic region. Springer C, et al. J Biol Chem, 1997 Oct 17. PMID 9334203
    3. Insight into gene fusion from molecular dynamics simulation of fused and un-fused IGPS (Imidazole Glycerol Phosphate Synthetase). Yiting Y, et al. Bioinformation, 2006 Feb 28. PMID 17611615, Free PMC Article
    4. Substrate-induced changes in the ammonia channel for imidazole glycerol phosphate synthase. Myers RS, et al. Biochemistry, 2003 Jun 17. PMID 12795596
    5. Crystal structure of imidazole glycerol phosphate synthase: a tunnel through a (beta/alpha)8 barrel joins two active sites. Chaudhuri BN, et al. Structure, 2001 Oct. PMID 11591353

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glutaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables imidazoleglycerol-phosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables imidazoleglycerol-phosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables imidazoleglycerol-phosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxo-acid-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-histidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    imidazoleglycerol-phosphate synthase
    NP_009807.3
    • Imidazole glycerol phosphate synthase; glutamine amidotransferase:cyclase that catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      714807..716465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178596.3 → NP_009807.3  TPA: imidazoleglycerol-phosphate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009807.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQP4, P33734
      UniProtKB/TrEMBL
      B3LMR4, C7GMY3, D3UEZ5, G2W9Q1, N1P9M2
      Conserved Domains (1) summary
      PLN02617
      Location:2 → 549
      PLN02617; imidazole glycerol phosphate synthase hisHF
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33734.2

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