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    SHG1 Shg1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852561, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SHG1
    Official Full Name
    Shg1p
    Primary source
    SGD:S000000462
    Locus tag
    YBR258C
    See related
    AllianceGenome:SGD:S000000462; FungiDB:YBR258C; VEuPathDB:YBR258C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CPS15
    Summary
    Contributes to histone methyltransferase activity (H3-K4 specific). Involved in histone H3-K4 methylation. Located in nucleus. Part of Set1C/COMPASS complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SHG1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (729734..730162, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene riboflavin synthase Neighboring gene RNase P/RNase MRP complex subunit Neighboring gene uncharacterized protein Neighboring gene GTPase-activating protein RGD1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cotranslational assembly of the yeast SET1C histone methyltransferase complex. Halbach A, et al. EMBO J, 2009 Oct 7. PMID 19713935, Free PMC Article
    2. Structural modeling of histone methyltransferase complex Set1C from Saccharomyces cerevisiae using constraint-based docking. Tuukkanen A, et al. Proteomics, 2010 Dec. PMID 21046623
    3. COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. Krogan NJ, et al. J Biol Chem, 2002 Mar 29. PMID 11805083
    4. Architecture and subunit arrangement of the complete Saccharomyces cerevisiae COMPASS complex. Wang Y, et al. Sci Rep, 2018 Nov 27. PMID 30479350, Free PMC Article
    5. Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex. Qu Q, et al. Cell, 2018 Aug 23. PMID 30100186, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone H3K4 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Shg1p
    NP_009817.3
    • Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      729734..730162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178606.3 → NP_009817.3  TPA: Shg1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009817.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQQ5, P38337
      UniProtKB/TrEMBL
      A6ZLJ8, B3LMQ3, D3UF06, G2W9R3
      Conserved Domains (1) summary
      pfam05205
      Location:10 → 126
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38337.1

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