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    APC5 anaphase promoting complex subunit 5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854423, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APC5
    Official Full Name
    anaphase promoting complex subunit 5
    Primary source
    SGD:S000005775
    Locus tag
    YOR249C
    See related
    AllianceGenome:SGD:S000005775; FungiDB:YOR249C; VEuPathDB:YOR249C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RMC1
    Summary
    Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process; chromatin assembly; and protein ubiquitination. Located in nucleus. Part of anaphase-promoting complex. Orthologous to human ANAPC5 (anaphase promoting complex subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See APC5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (798674..800731, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Env9p Neighboring gene Srl1p Neighboring gene cleavage polyadenylation factor subunit CLP1 Neighboring gene thiosulfate sulfurtransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex. Postnikoff SD, et al. PLoS Genet, 2012. PMID 22438832, Free PMC Article
    2. The anaphase promoting complex regulates yeast lifespan and rDNA stability by targeting Fob1 for degradation. Menzel J, et al. Genetics, 2014 Mar. PMID 24361936, Free PMC Article
    3. Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast. Islam A, et al. Cell Div, 2011 Jun 8. PMID 21651791, Free PMC Article
    4. The ubiquitin-dependent targeting pathway in Saccharomyces cerevisiae plays a critical role in multiple chromatin assembly regulatory steps. Harkness TA, et al. Genetics, 2002 Oct. PMID 12399376, Free PMC Article
    5. Novel interaction between Apc5p and Rsp5p in an intracellular signaling pathway in Saccharomyces cerevisiae. Arnason TG, et al. Eukaryot Cell, 2005 Jan. PMID 15643069, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APC is required for histone synthesis and histone metabolism in mitotically active cells as shown by its interaction with Elp3/Gcn5.
      Title: The Saccharomyces cerevisiae anaphase-promoting complex interacts with multiple histone-modifying enzymes to regulate cell cycle progression.
    2. Apc5p and Rsp5p have roles in an intracellular signaling pathway in Saccharomyces cerevisiae
      Title: Novel interaction between Apc5p and Rsp5p in an intracellular signaling pathway in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anaphase promoting complex subunit 5
    NP_014892.3
    • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      798674..800731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183668.3 → NP_014892.3  TPA: anaphase promoting complex subunit 5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014892.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2V0, Q08683
      UniProtKB/TrEMBL
      C7GWE0, N1NYR5
      Conserved Domains (2) summary
      sd00016
      Location:296 → 330
      Apc5; TPR repeat [structural motif]
      pfam12862
      Location:302 → 390
      ANAPC5; Anaphase-promoting complex subunit 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08683.1

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