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    PEX12 ubiquitin-protein ligase peroxin 12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855041, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PEX12
    Official Full Name
    ubiquitin-protein ligase peroxin 12
    Primary source
    SGD:S000004628
    Locus tag
    YMR026C
    See related
    AllianceGenome:SGD:S000004628; FungiDB:YMR026C; VEuPathDB:YMR026C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PAS11
    Summary
    Enables ubiquitin protein ligase activity. Involved in protein import into peroxisome matrix and protein monoubiquitination. Is integral component of peroxisomal membrane. Part of peroxisomal importomer complex. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 3A. Orthologous to human PEX12 (peroxisomal biogenesis factor 12). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PEX12 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (324236..325435, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL3 Neighboring gene Csi1p Neighboring gene putative methyltransferase Neighboring gene Tap42p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peroxisome remnants in pex3delta cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes. Hazra PP, et al. Traffic, 2002 Aug. PMID 12121419
    2. Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders. Chang CC, et al. Nat Genet, 1997 Apr. PMID 9090384
    3. Pex12p of Saccharomyces cerevisiae is a component of a multi-protein complex essential for peroxisomal matrix protein import. Albertini M, et al. Eur J Cell Biol, 2001 Apr. PMID 11370741
    4. The RING-type ubiquitin ligases Pex2p, Pex10p and Pex12p form a heteromeric complex that displays enhanced activity in an ubiquitin conjugating enzyme-selective manner. El Magraoui F, et al. FEBS J, 2012 Jun. PMID 22471590
    5. Distinct ubiquitination cascades act on the peroxisomal targeting signal type 2 co-receptor Pex18p. El Magraoui F, et al. Traffic, 2013 Dec. PMID 24034674

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin ligase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into peroxisome matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix, receptor recycling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of peroxisomal importomer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of peroxisomal importomer complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-protein ligase peroxin 12
    NP_013739.1
    • C3HC4-type RING-finger peroxin and E3 ubiquitin ligase; required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      324236..325435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182522.1 → NP_013739.1  TPA: ubiquitin-protein ligase peroxin 12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013739.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZK0, Q04370, Q6B1L4
      UniProtKB/TrEMBL
      A6ZM88, B3LLS7, B5VPF3, C7GL93, C8ZEN3, G2WK77, N1NYM0
      Conserved Domains (2) summary
      cd16451
      Location:334 → 375
      mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins
      pfam04757
      Location:41 → 295
      Pex2_Pex12; Pex2 / Pex12 amino terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04370.1

    Gene LinkOut

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