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    IMD3 IMP dehydrogenase IMD3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851152, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IMD3
    Official Full Name
    IMP dehydrogenase IMD3
    Primary source
    SGD:S000004424
    Locus tag
    YLR432W
    See related
    AllianceGenome:SGD:S000004424; FungiDB:YLR432W; VEuPathDB:YLR432W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Predicted to be involved in GTP biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to several human genes including IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See IMD3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1002557..1004128)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene DNA/RNA helicase SEN1 Neighboring gene Atg23p Neighboring gene calcineurin catalytic subunit A Neighboring gene Tsr2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid. Köhler GA, et al. J Bacteriol, 1997 Apr. PMID 9079920, Free PMC Article
    2. Dissection of the molecular basis of mycophenolate resistance in Saccharomyces cerevisiae. Jenks MH, et al. Yeast, 2005 Nov. PMID 16278936
    3. Participation of yeast inosine 5'-monophosphate dehydrogenase in an in vitro complex with a fragment of the C-rich telomeric strand. Cornuel JF, et al. Biochimie, 2002 Apr. PMID 12106905
    4. Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. Hyle JW, et al. J Biol Chem, 2003 Aug 1. PMID 12746440, Free PMC Article
    5. IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II. Park JH, et al. Biochem Biophys Res Commun, 2010 Feb 19. PMID 20097157

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables IMP dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IMP dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables IMP dehydrogenase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GTP biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    IMP dehydrogenase IMD3
    NP_013536.3
    • Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD3 has a paralog, IMD4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1002557..1004128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182320.3 → NP_013536.3  TPA: IMP dehydrogenase IMD3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013536.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ67, P50095
      UniProtKB/TrEMBL
      A7A1V2, B3RHU1, C7GSM3, C8ZE40, G2WJP3, N1P1X9
      Conserved Domains (1) summary
      PTZ00314
      Location:21 → 518
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50095.1

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