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    MIR646HG MIR646 host gene [ Homo sapiens (human) ]

    Gene ID: 284757, updated on 17-Jun-2024

    Summary

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    Official Symbol
    MIR646HGprovided by HGNC
    Official Full Name
    MIR646 host geneprovided by HGNC
    Primary source
    HGNC:HGNC:27659
    See related
    Ensembl:ENSG00000228340 AllianceGenome:HGNC:27659
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See MIR646HG in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (60138492..60322256)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (61922778..62107446)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (58713548..58897314)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18193 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:58633003-58633804 Neighboring gene long intergenic non-protein coding RNA 2910 Neighboring gene uncharacterized LOC729296 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:58677553-58677708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:58686253-58686792 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:58786198-58786437 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:58788309-58788809 Neighboring gene uncharacterized LOC105372698 Neighboring gene NANOG hESC enhancer GRCh37_chr20:58847405-58847906 Neighboring gene uncharacterized LOC105372697 Neighboring gene microRNA 646 Neighboring gene MT-CO2 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MiR-646 regulates proliferation and migration of laryngeal carcinoma through the PI3K/AKT pathway via targeting GPX1. Yuan X, et al. Oral Dis, 2021 Oct. PMID 33150676
    2. New susceptibility loci associated with kidney disease in type 1 diabetes. Sandholm N, et al. PLoS Genet, 2012 Sep. PMID 23028342, Free PMC Article
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-646 regulates proliferation and migration of laryngeal carcinoma through the PI3K/AKT pathway via targeting GPX1.
      Title: MiR-646 regulates proliferation and migration of laryngeal carcinoma through the PI3K/AKT pathway via targeting GPX1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    New susceptibility loci associated with kidney disease in type 1 diabetes.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • MIR646 host gene (non-protein coding)

    Clone Names

    • FLJ46426

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_046099.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK092805, AL035070
      Related
      ENST00000432910.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      60138492..60322256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      61922778..62107446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001004305.1: Suppressed sequence

      Description
      NM_001004305.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate, and because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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